De Curtis M, Paone C, Vetrano G, Romano G, Paludetto R, Ciccimarra F
Istituto di Medicina dell'Età Evolutiva, II Facoltà di Medicina & Chirurgia, Napoli, Italy.
Eur J Pediatr. 1987 Jul;146(4):398-400. doi: 10.1007/BF00444947.
The perinatal histories of 27 newborn infants with NEC were compared to those of 54 infants of equivalent birth weight who did not have NEC during an 8-year study period to see if possible predisposing factors were independent of the confounding effect of birth weight. No differences were observed in gestational age, degree of intrauterine growth retardation, premature rupture of membranes, perinatal asphyxia, skin temperature at admission, haematocrit, presence or absence of respiratory distress syndrome, umbilical catheter placement, start and type of feeding or presence of positive blood cultures. Prematurity is the greatest risk factor predisposing to the development of NEC and the perinatal problems which precede the onset of NEC are common among all premature infants.
在一项为期8年的研究中，将27例患有坏死性小肠结肠炎（NEC）的新生儿的围产期病史与54例出生体重相当但未患NEC的婴儿的病史进行比较，以确定可能的诱发因素是否独立于出生体重的混杂效应。在胎龄、宫内生长迟缓程度、胎膜早破、围产期窒息、入院时皮肤温度、血细胞比容、是否存在呼吸窘迫综合征、脐导管放置、喂养开始时间和类型或血培养阳性方面均未观察到差异。早产是导致NEC发生的最大风险因素，NEC发作前的围产期问题在所有早产儿中都很常见。
