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以叔丁基过氧化氢为氧化剂和反应物，由苯硫酚和二硫化物合成β-羟基硫醚

Synthesis of β-Hydroxysulfides from Thiophenols and Disulfides with tert-Butyl Hydroperoxide as the Oxidant and Reactant.

作者信息

Feng Jian-Bo, Wu Xiao-Feng

机构信息

Department of Chemistry Zhejiang Sci-Tech University Xiasha Campus Hangzhou Zhejiang Province 310018 P. R. China; Leibniz-Institut für Katalyse e.V. an der Universität Rostock Albert-Einstein-Strasse 29a18059 Rostock Germany.

出版信息

ChemistryOpen. 2016 May 17;5(4):315-8. doi: 10.1002/open.201600023. eCollection 2016 Aug.

DOI:10.1002/open.201600023
PMID:27547640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4981051/
Abstract

In this Communication, we developed a new procedure for the synthesis of β-hydroxysulfides from thiophenols or diaryl disulfides with TBHP as the oxidant. In the presence of zinc iodide or potassium iodide, with TBHP as the oxidant and pre-reactant, thiophenols and diaryl disulfides reacted with the methyl group of tBuOH smoothly and selectivity to give the corresponding 2-methyl-1-(arylthio)propan-2-ols as the terminal products in moderate to good yields.

摘要

在本通讯中，我们开发了一种以叔丁基过氧化氢（TBHP）作为氧化剂，从硫酚或二芳基二硫化物合成β-羟基硫醚的新方法。在碘化锌或碘化钾存在下，以TBHP作为氧化剂和预反应物，硫酚和二芳基二硫化物与叔丁醇的甲基顺利且选择性地反应，以中等至良好的产率得到相应的2-甲基-1-（芳硫基）丙-2-醇作为终产物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68c/4981051/0e78d78b5f10/OPEN-5-315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68c/4981051/97dd05b34998/OPEN-5-315-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68c/4981051/0e78d78b5f10/OPEN-5-315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68c/4981051/97dd05b34998/OPEN-5-315-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68c/4981051/0e78d78b5f10/OPEN-5-315-g002.jpg

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