基于马尔默饮食与癌症队列研究中的饮食质量指数，血脂异常的遗传易感性与心血管疾病发病率的关系

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort.

作者信息

Hellstrand Sophie, Ericson Ulrika, Schulz Christina-Alexandra, Drake Isabel, Gullberg Bo, Hedblad Bo, Engström Gunnar, Orho-Melander Marju, Sonestedt Emily

机构信息

Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden.

Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden.

出版信息

Genes Nutr. 2016 Jul 7;11:20. doi: 10.1186/s12263-016-0536-0. eCollection 2016.

DOI:10.1186/s12263-016-0536-0

PMID:27551321

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4968442/

Abstract

BACKGROUND

By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent results regarding genetically elevated high-density lipoprotein-cholesterol (HDL-C), and cardiovascular disease (CVD) risk.

METHODS

We included 24,799 participants (62 % women, age 44-74 years) from the Malmö Diet and Cancer cohort. During a mean follow-up time of 15 years, 3068 incident CVD cases (1814 coronary and 1254 ischemic stroke) were identified. Genetic risk scores (GRSs) were constructed by combining 80 validated genetic variants associated with higher TG and LDL-C or lower HDL-C. The participants' dietary intake, assessed by a modified diet history method, was ranked according to a diet quality index that included six dietary components: saturated fat, polyunsaturated fat, fish, fiber, fruit and vegetables, and sucrose.

RESULTS

The GRSLDL-C (P = 5 × 10(-6)) and GRSHDL-C (P = 0.02) but not GRSTG (P = 0.08) were significantly associated with CVD risk. No significant interaction between the GRSs and diet quality was observed on CVD risk (P > 0.39). A high compared to a low diet quality attenuated the association between GRSLDL-C and the risk of incident ischemic stroke (P interaction = 0.01).

CONCLUSION

We found some evidence of an interaction between diet quality and GRSLDL-C on ischemic stroke.

摘要

背景

通过考虑饮食质量，我们或许能够阐明基因导致的甘油三酯（TG）升高与低密度脂蛋白胆固醇（LDL-C）之间的关系，并更好地理解关于基因导致的高密度脂蛋白胆固醇（HDL-C）升高和心血管疾病（CVD）风险的不一致结果。

方法

我们纳入了来自马尔默饮食与癌症队列的24799名参与者（62%为女性，年龄44 - 74岁）。在平均15年的随访期内，共识别出3068例新发CVD病例（1814例冠心病和1254例缺血性中风）。通过合并80个与较高TG、LDL-C或较低HDL-C相关的经过验证的基因变异构建遗传风险评分（GRS）。采用改良饮食史方法评估参与者的饮食摄入量，并根据包含六种饮食成分（饱和脂肪、多不饱和脂肪、鱼类、纤维、水果和蔬菜以及蔗糖）的饮食质量指数进行排名。

结果

GRSLDL-C（P = 5×10⁻⁶）和GRSHDL-C（P = 0.02）而非GRSTG（P = 0.08）与CVD风险显著相关。未观察到GRS与饮食质量之间在CVD风险上存在显著交互作用（P > 0.39）。与低饮食质量相比，高饮食质量减弱了GRSLDL-C与缺血性中风发病风险之间的关联（P交互作用 = 0.01）。