一项利用完整线粒体基因组的下一代测序技术对格陵兰岛人口迁徙情况的研究。
A study of the peopling of Greenland using next generation sequencing of complete mitochondrial genomes.
作者信息
Lopopolo Maria, Børsting Claus, Pereira Vania, Morling Niels
机构信息
Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100, Copenhagen, Denmark.
出版信息
Am J Phys Anthropol. 2016 Dec;161(4):698-704. doi: 10.1002/ajpa.23074. Epub 2016 Aug 24.
OBJECTIVES
The Greenlandic population history is characterized by a number of migrations of people of various ethnicities. In this work, the analysis of the complete mtDNA genome aimed to contribute to the ongoing debate on the origin of current Greenlanders and, at the same time, to address the migration patterns in the Greenlandic population from a female inheritance demographic perspective.
METHODS
We investigated the maternal genetic variation in the Greenlandic population by sequencing the whole mtDNA genome in 127 Greenlandic individuals using the Illumina MiSeq platform.
RESULTS
All Greenlandic individuals belonged to the Inuit mtDNA lineages A2a, A2b1, and D4b1a2a1. No European haplogroup was found.
DISCUSSION
The mtDNA lineages seem to support the hypothesis that the Inuit in Greenland are descendants from the Thule migration. The results also reinforce the importance of isolation and genetic drift in shaping the genetic diversity in Greenlanders. Based on the mtDNA sequences, the Greenlandic Inuit are phylogenetically close to Siberian groups and Canadian Inuit.
目的
格陵兰岛的人口历史具有多个不同种族人群迁徙的特点。在这项研究中，对完整线粒体DNA基因组进行分析旨在为当前关于格陵兰岛人起源的持续争论做出贡献，同时从女性遗传人口统计学角度探讨格陵兰岛人群的迁徙模式。
方法
我们使用Illumina MiSeq平台对127名格陵兰岛个体的整个线粒体DNA基因组进行测序，以研究格陵兰岛人群中的母系遗传变异。
结果
所有格陵兰岛个体均属于因纽特人线粒体DNA谱系A2a、A2b1和D4b1a2a1。未发现欧洲单倍群。
讨论
线粒体DNA谱系似乎支持这样一种假说，即格陵兰岛的因纽特人是图勒人迁徙的后裔。研究结果还强化了隔离和遗传漂变在塑造格陵兰岛人遗传多样性方面的重要性。基于线粒体DNA序列，格陵兰岛因纽特人与西伯利亚群体和加拿大因纽特人在系统发育上关系密切。
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