混合性生殖细胞松果体肿瘤的内镜组织学图谱
Endoscopic Histologic Mapping of a Mixed Germ Pineal Tumor.
作者信息
Velásquez Carlos, Rivero-Garvía Mónica, Rivas Eloy, Cañizares María de Los Angeles, Mayorga-Buiza María José, Márquez-Rivas Javier
机构信息
Department of Neurological Surgery and Spine Unit, Hospital Universitario Marqués de Valdecilla and Fundación Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Spain.
Department of Neurosurgery, Hospitales Universitarios Virgen del Rocio, Seville, Spain.
出版信息
World Neurosurg. 2016 Nov;95:625.e1-625.e5. doi: 10.1016/j.wneu.2016.08.043. Epub 2016 Aug 23.
BACKGROUND
The accurate histologic diagnosis of germ cell tumors in the pineal region is a keystone for determining the best treatment strategy and prognosis. This situation poses a challenge for the neuropathologist, considering the lack of a standarized procedure to obtain biopsy samples, which results in few and small specimens, which are not suitable for diagnosis.
CASE DESCRIPTION
We report a case in which a pineal region mixed germ cell tumor was accurately diagnosed by performing histologic mapping through a dual burr-hole endoscopic approach. The technical pitfalls and other considerations necessary for obtaining an accurate diagnosis in this tumor subgroup are specified. In addition, the histologic analysis regarding the sampling technique used is described.
CONCLUSIONS
The supraorbital frontal endoscopic approach enables the surgeon to perform histologic mapping of pineal region tumors, allowing standarization of the procedure used to obtain the specimens. This approach could result in a more accurate diagnosis, especially in mixed germ cell neoplasms.
背景
松果体区生殖细胞肿瘤的准确组织学诊断是确定最佳治疗策略和预后的关键。考虑到获取活检样本缺乏标准化程序，导致样本数量少且体积小，不适合诊断，这种情况给神经病理学家带来了挑战。
病例描述
我们报告了一例通过双骨孔内镜方法进行组织学定位而准确诊断松果体区混合性生殖细胞肿瘤的病例。明确了该肿瘤亚组获得准确诊断所需的技术陷阱和其他注意事项。此外，还描述了所用采样技术的组织学分析。
结论
眶上额部内镜方法使外科医生能够对松果体区肿瘤进行组织学定位，使获取标本的程序标准化。这种方法可能会导致更准确的诊断，尤其是在混合性生殖细胞肿瘤中。
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