Griffis Joseph C, Elkhetali Abdurahman S, Burge Wesley K, Chen Richard H, Bowman Anthony D, Szaflarski Jerzy P, Visscher Kristina M
Department of Psychology, University of Alabama at Birmingham, United States.
Department of Neurobiology, University of Alabama at Birmingham, United States.
Neuroimage. 2017 Feb 1;146:1071-1083. doi: 10.1016/j.neuroimage.2016.08.035. Epub 2016 Aug 20.
Psychophysical and neurobiological evidence suggests that central and peripheral vision are specialized for different functions. This specialization of function might be expected to lead to differences in the large-scale functional interactions of early cortical areas that represent central and peripheral visual space. Here, we characterize differences in whole-brain functional connectivity among sectors in primary visual cortex (V1) corresponding to central, near-peripheral, and far-peripheral vision during resting fixation. Importantly, our analyses reveal that eccentricity sectors in V1 have different functional connectivity with non-visual areas associated with large-scale brain networks. Regions associated with the fronto-parietal control network are most strongly connected with central sectors of V1, regions associated with the cingulo-opercular control network are most strongly connected with near-peripheral sectors of V1, and regions associated with the default mode and auditory networks are most strongly connected with far-peripheral sectors of V1. Additional analyses suggest that similar patterns are present during eyes-closed rest. These results suggest that different types of visual information may be prioritized by large-scale brain networks with distinct functional profiles, and provide insights into how the small-scale functional specialization within early visual regions such as V1 relates to the large-scale organization of functionally distinct whole-brain networks.
心理物理学和神经生物学证据表明，中央视觉和周边视觉专门用于不同的功能。这种功能特化可能会导致在代表中央和周边视觉空间的早期皮质区域的大规模功能相互作用中出现差异。在这里，我们描述了在静息注视期间，初级视觉皮层（V1）中对应于中央、近周边和远周边视觉的各扇形区域之间全脑功能连接的差异。重要的是，我们的分析表明，V1中的离心率扇形区域与与大规模脑网络相关的非视觉区域具有不同的功能连接。与额顶叶控制网络相关的区域与V1的中央扇形区域连接最强，与扣带回-脑岛控制网络相关的区域与V1的近周边扇形区域连接最强，与默认模式和听觉网络相关的区域与V1的远周边扇形区域连接最强。进一步分析表明，闭眼休息期间也存在类似模式。这些结果表明，不同类型的视觉信息可能会被具有不同功能特征的大规模脑网络赋予不同优先级，并为诸如V1等早期视觉区域内的小规模功能特化如何与功能不同的全脑网络的大规模组织相关联提供了见解。
