Corvi Raffaella, Madia Federica
European Commission, Joint Research Centre (JRC), Directorate Health, Consumers and Reference Materials, Chemicals Safety and Alternative Methods Unit, EURL ECVAM, Via E. Fermi 2749, I-21027, Ispra, Varese, Italy.
Food Chem Toxicol. 2017 Aug;106(Pt B):600-608. doi: 10.1016/j.fct.2016.08.024. Epub 2016 Aug 21.
The assessment of genotoxicity represents an essential component of the safety assessment of all types of substances. Several in vitro tests are available at different stages of development and acceptance, yet they are not considered at present sufficient to fully replace animal tests needed to evaluate the safety of substances. For an overall improvement of the traditional genotoxicity testing paradigm, several recent activities have taken place. These include the improvement of existing tests, the development of novel tests, as well as, the establishment and exploration of approaches to optimise in vitro testing accuracy. Furthermore, useful tools, such as databases or reference chemical lists have been developed to support advances in this field.
遗传毒性评估是各类物质安全性评估的重要组成部分。在不同的开发和认可阶段有多种体外试验可用，但目前认为这些试验不足以完全取代评估物质安全性所需的动物试验。为了全面改进传统的遗传毒性测试模式，最近开展了多项活动。这些活动包括改进现有试验、开发新试验，以及建立和探索优化体外试验准确性的方法。此外，还开发了数据库或参考化学品清单等有用工具，以支持该领域的进展。
