Pradhan Saurabh, Ghimire Ashish, Bhattarai Balkrishna, Khanal Bashudha, Pokharel Krishna, Lamsal Madhab, Koirala Sidhhartha
Department of Anaesthesiology, TUTH, IOM, Kathmandu, Nepal.
Department of Anaesthesiology and Critical Care, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
Indian J Crit Care Med. 2016 Jul;20(7):417-20. doi: 10.4103/0972-5229.186226.
C-reactive protein (CRP) is a commonly used biomarker of sepsis, the leading cause of mortality in Intensive Care Units (ICUs). However, sufficient data are still lacking to strongly recommend it in clinical practice. The present study is aimed to find out its reliability in diagnosing sepsis.
CRP was measured in ICU-admitted patients with systemic inflammatory response syndrome and compared using a cutoff of 50 mg/L with the gold standard for diagnosing sepsis, taken as isolation of organism from a suspected source of infection or the Centers for Disease Control criteria for clinical sepsis.
CRP had a sensitivity and specificity of 84.3% and 46.15%, respectively. Area under the receiver operating characteristics curve was calculated to be 0.683 (±0.153, P < 0.05). The cutoff value with the best diagnostic accuracy was found to be 61 mg/L.
CRP is a sensitive marker of sepsis, but it is not specific.
C反应蛋白（CRP）是脓毒症常用的生物标志物，脓毒症是重症监护病房（ICU）死亡的主要原因。然而，仍缺乏足够的数据来在临床实践中强烈推荐使用它。本研究旨在查明其在诊断脓毒症方面的可靠性。
对入住ICU且患有全身炎症反应综合征的患者测量CRP，并使用50mg/L的临界值与脓毒症诊断的金标准进行比较，脓毒症诊断的金标准为从疑似感染源分离出病原体或疾病控制中心的临床脓毒症标准。
CRP的敏感性和特异性分别为84.3%和46.15%。计算得出受试者工作特征曲线下面积为0.683（±0.153，P<0.05）。发现诊断准确性最佳的临界值为61mg/L。
CRP是脓毒症的敏感标志物，但不具有特异性。
