Department of Clinical Biochemistry, Kathmandu University School of Medical Sciences, B.P Highway, Panauti, Kavrepalanchok, Nepal.
Department of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, Australia.
JNMA J Nepal Med Assoc. 2021 Dec 11;59(244):1247-1251. doi: 10.31729/jnma.7047.
Sepsis is the most common cause of mortality among patients admitted to intensive care unit. There is emerging evidence on the role of C-reactive protein to albumin ratio (C-reactive protein/Albumin) in predicting outcomes in patients with critical illness and sepsis, admitted to intensive care unit. We aimed to find out the median value of C-reactive protein/Albumin ratio among patients admitted to intensive care unit of a tertiary care hospital.
We conducted a descriptive cross-sectional study of 110 critically ill patients (>18 years old) admitted to intensive care unit of Dhulikhel Hospital from April, 2014 to June, 2016. The ethical approval (Reference number.51/16) was obtained from Institutional Review Committee at Kathmandu University School of Medical Sciences. C-reactive protein/albumin ratio was calculated from records of patients admitted to the intensive care unit. Convenience sampling was done. Data were entered into Microsoft Excel and analysed using Statistical Package for Social Sciences version 20. Point estimate at 95% Confidence Interval was calculated along with frequencies and percentages for binary data.
Among 110 patients admitted to the intensive care unit, the median value of C-reactive protein/Albumin ratio was found to be 3.4 (Interquartile range: 3.1-4.5). Out of these patients, 44 (39.5%) patients were septic and their median C-reactive protein/albumin ratio was 3.4 (Interquartile range: 3.1-4.5).
Our study showed higher median C-reactive protein /Albumin similar to other studies. Sepsis is a common finding among patients admitted to intensive care unit. Monitoring of C-reactive protein/albumin level in a patient admitted to intensive care unit could be useful for stratifying patients with a high risk of developing sepsis.
败血症是重症监护病房患者死亡的最常见原因。有越来越多的证据表明 C 反应蛋白与白蛋白比值（C 反应蛋白/白蛋白）在预测重症监护病房危重病和败血症患者的结局方面具有重要作用。我们旨在确定三级医院重症监护病房患者的 C 反应蛋白/白蛋白比值的中位数。
我们对 2014 年 4 月至 2016 年 6 月期间在 Dhulikhel 医院重症监护病房收治的 110 名危重病患者（>18 岁）进行了描述性横断面研究。该研究获得了 Kathmandu 大学医学院机构审查委员会的伦理批准（参考号 51/16）。从重症监护病房患者的记录中计算 C 反应蛋白/白蛋白比值。采用便利抽样。数据录入 Microsoft Excel 并使用社会科学统计软件包 20 版进行分析。计算了 95%置信区间的点估计值以及二进制数据的频率和百分比。
在 110 名入住重症监护病房的患者中，C 反应蛋白/白蛋白比值的中位数为 3.4（四分位间距：3.1-4.5）。在这些患者中，44 名（39.5%）患者患有败血症，他们的中位 C 反应蛋白/白蛋白比值为 3.4（四分位间距：3.1-4.5）。
我们的研究显示，与其他研究相似，较高的 C 反应蛋白/白蛋白比值的中位数。败血症是重症监护病房患者的常见病症。监测入住重症监护病房患者的 C 反应蛋白/白蛋白水平可能有助于对发生败血症风险较高的患者进行分层。
