Pagliarin Claudia Medianeira Londero, Londero Clacir de Lourdes Dotto, Felippe Mara Cristina Santos, Felippe Wilson Tadeu, Danesi Cristiane Cademartori, Barletta Fernando Branco
Universidade Federal de Santa Maria - UFSM, School of Dentistry, Department of Stomatology, Santa Maria, RS, Brazil.
Universidade Federal de Santa Maria - UFSM, School of Dentistry, Dental Service, Santa Maria, RS, Brazil.
Braz Oral Res. 2016 Aug 18;30(1):S1806-83242016000100273. doi: 10.1590/1807-3107BOR-2016.vol30.0074.
Revascularization of immature teeth with necrotic pulps traditionally involves the use of triple antibiotic paste, which may sometimes lead to undesirable complications. The objective of this study was to assess tissue repair in immature dog teeth with apical periodontitis subjected to revascularization, comparing two different pastes used for root canal disinfection. Apical periodontitis was induced in 30 dog premolars. Teeth were randomly divided into three experimental groups: root canals filled with triple antibiotic paste (n = 10); root canals filled with 1% propolis paste (n = 10); and no medication (n = 10). An additional group (n = 10, no intervention) was used as control. After 7 months, the jaws were histologically evaluated for the following variables: newly formed mineralized tissue (present/absent); vital tissue in the canal space (absent/periodontal ligament-like/pulp-like); apical extension of root (present/absent); and severity of inflammatory process (absent/mild/moderate/severe). There were no statistically significant differences among the experimental groups in new mineralized tissue formation and apical root development. The formation of vital tissue in the canal space, in turn, was statistically different between the triple paste and propolis groups: vital tissues were present in all revascularized teeth disinfected with propolis paste (100%), compared to 71% of those disinfected with the triple paste. Severity of inflammatory process was different between the triple paste and no medication groups. The new tissues formed onto canal walls and in the root canal space showed characteristics of cementum and periodontal ligament, respectively. Propolis may have some advantages over the triple paste for the revascularization of immature teeth.
传统上，对牙髓坏死的未成熟牙齿进行血管再生治疗时会使用三联抗生素糊剂，但有时可能会导致不良并发症。本研究的目的是评估根尖周炎的未成熟犬牙在进行血管再生治疗后的组织修复情况，比较两种用于根管消毒的不同糊剂。在30颗犬前磨牙中诱导根尖周炎。将牙齿随机分为三个实验组：根管填充三联抗生素糊剂（n = 10）；根管填充1%蜂胶糊剂（n = 10）；不使用药物（n = 10）。另外一组（n = 10，不干预）作为对照组。7个月后，对颌骨进行组织学评估，观察以下变量：新形成的矿化组织（存在/不存在）；根管空间内的活组织（不存在/牙周韧带样/牙髓样）；牙根的根尖延伸（存在/不存在）；以及炎症过程的严重程度（不存在/轻度/中度/重度）。实验组之间在新矿化组织形成和根尖牙根发育方面没有统计学上的显著差异。相反，根管空间内活组织的形成在三联糊剂组和蜂胶组之间存在统计学差异：在用蜂胶糊剂消毒的所有血管再生牙齿中均存在活组织（100%），而在用三联糊剂消毒的牙齿中这一比例为71%。三联糊剂组和不使用药物组在炎症过程的严重程度上有所不同。在根管壁上和根管空间内新形成的组织分别显示出牙骨质和牙周韧带的特征。对于未成熟牙齿的血管再生治疗，蜂胶可能比三联糊剂具有一些优势。
