Panda Pratima, Mishra Lora, Govind Shashirekha, Panda Saurav, Lapinska Barbara
Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751003, Odisha, India.
Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751003, Odisha, India.
J Clin Med. 2022 Jul 5;11(13):3909. doi: 10.3390/jcm11133909.
This systematic review aimed to evaluate interventions individually and compare the clinical outcome of young, immature teeth treated with regenerative endodontic therapy (RET) and apexification procedure. The protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews), bearing the registration number CRD42021230284. A bibliographic search in the biomedical databases was conducted in four databases-PubMed, CENTRAL, EMBASE and ProQuest-using searching keywords and was limited to studies published between January 2000 and April 2022 in English. The search was supplemented by manual searching, citation screening and scanning of all reference lists of selected paper. The study selection criteria were randomized clinical trial, prospective clinical studies and observational studies. The search found 32 eligible articles, which were included in the study. The quality assessment of the studies was performed using the Cochrane risk of bias tool for randomized control trials and non-randomized clinical studies. The meta-analysis was performed using Review Manager software (REVMAN, version 5). The results indicated that a clinicians' MTA apexification procedure was more successful compared to calcium hydroxide. In RET, apical closure and overall success rate is statistically same for both apical platelet concentrates (APCs) and blood clots (BC). Both interventions have similar survival rates; however, RET should be preferred in cases where the root development is severely deficient, there is insufficient dentine and the tooth's prognosis is hopeless even with an apexification procedure.
本系统评价旨在单独评估干预措施，并比较采用再生性牙髓治疗（RET）和根尖诱导成形术治疗的年轻恒牙的临床结果。该方案已在国际系统评价前瞻性注册库（PROSPERO）注册，注册号为CRD42021230284。在四个生物医学数据库——PubMed、CENTRAL、EMBASE和ProQuest中，使用检索关键词进行文献检索，检索范围限于2000年1月至2022年4月以英文发表的研究。通过手工检索、引文筛选和扫描所选论文的所有参考文献列表对检索进行补充。研究选择标准为随机临床试验、前瞻性临床研究和观察性研究。检索发现32篇符合条件的文章，并纳入本研究。使用Cochrane偏倚风险工具对随机对照试验和非随机临床研究进行研究质量评估。使用Review Manager软件（REVMAN，版本5）进行荟萃分析。结果表明，与氢氧化钙相比，临床医生进行的MTA根尖诱导成形术更成功。在RET中，根尖血小板浓缩物（APC）和血凝块（BC）的根尖闭合和总体成功率在统计学上相同。两种干预措施的生存率相似；然而，在牙根发育严重不足、牙本质不足且即使进行根尖诱导成形术牙齿预后仍无望的情况下，应首选RET。
