Zhao Jia
VIP Dental Service, Jinan Stomatological Hospital, Jinan 250001, Shandong, China.
Evid Based Complement Alternat Med. 2022 Jun 27;2022:3610461. doi: 10.1155/2022/3610461. eCollection 2022.
To evaluate the application of hydrogel scaffold materials and triple antibiotic paste in endodontic regeneration through literature review.
An electronic search of the literature published on PubMed, Wangfang database, and CNKI database using the search terms "endodontic regeneration," "pulp blood flow reconstruction," "recanalization," "triple antibiotic paste," and "scaffold material" was conducted. The searched literature was used for analysis. Hydrogels regulate stem cell fates, modulate growth factor release, and encapsulate antibacterial and anti-inflammatory drugs. The triple antibiotic paste is composed of metronidazole, ciprofloxacin, and minocycline, which exhibits promising antibacterial effects and duration at appropriate concentrations, with low cytotoxicity, and effectively promotes the preservation and regeneration of pulp tissues and the formation of dental hard tissues. However, issues such as tooth discoloration and bacterial drug resistance also exist. The present article reviews the progress of research on the application of hydrogel scaffold materials and triple antibiotic paste in endodontic revascularization.
通过文献综述评估水凝胶支架材料和三联抗生素糊剂在牙髓再生中的应用。
使用“牙髓再生”“牙髓血流重建”“再通”“三联抗生素糊剂”和“支架材料”等检索词，对发表在PubMed、万方数据库和中国知网数据库上的文献进行电子检索。对检索到的文献进行分析。水凝胶可调节干细胞命运、调节生长因子释放并包裹抗菌和抗炎药物。三联抗生素糊剂由甲硝唑、环丙沙星和米诺环素组成，在适当浓度下具有良好的抗菌效果和持续时间，细胞毒性低，并能有效促进牙髓组织的保存和再生以及牙硬组织的形成。然而，也存在牙齿变色和细菌耐药性等问题。本文综述了水凝胶支架材料和三联抗生素糊剂在牙髓血管再生应用中的研究进展。
