Min Kyungdong, Kwon Seungwon, Cho Seung-Yeon, Choi Woo Jun, Park Seong-Uk, Jung Woo-Sang, Moon Sang-Kwan, Park Jung-Mi, Ko Chang-Nam, Cho Ki-Ho
Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
Department of Korean Medicine Cardiology and Neurology, Graduate School, Kyung Hee University, Seoul, Korea.
J Clin Lab Anal. 2017 Mar;31(2). doi: 10.1002/jcla.22041. Epub 2016 Aug 25.
No study has investigated the relationship between hospital-admission neutrophil and lymphocyte ratio (NLR) and various stroke risk factors. We sought to determine which stroke risk factor could be the most appropriate predictor of NLR in acute ischemic stroke.
We collected data on various stroke risk factors and National Institutes of Health Stroke Scale (NIHSS) score in 1,053 acute ischemic stroke patients. The regression analysis was adjusted for confounding factors such as stroke risk factors.
There was a trend of increased NLR with a rise in alcohol consumption, the prevalence of hypertension, cardioembolism (CE) etiology, the NIHSS scores in men and the prevalence of atrial fibrillation, other heart diseases, CE and small vessel occlusion etiology and the NIHSS scores in women. Multiple linear regression analyses, adjusted for confounding factors, showed that the atrial fibrillation and NIHSS scores in men and atrial fibrillation, diabetes mellitus as well as NIHSS scores in women had a significant positive association with NLR. However, a negative association was showed for body mass index (BMI).
We confirmed that the atrial fibrillation can be a predictor of high NLR in acute stroke patients, and diabetes mellitus as well as low BMI could be a predictor of high NLR in female acute ischemic stroke patients.
尚无研究探讨入院时中性粒细胞与淋巴细胞比值（NLR）与各种中风危险因素之间的关系。我们试图确定哪种中风危险因素可能是急性缺血性中风中NLR最合适的预测指标。
我们收集了1053例急性缺血性中风患者的各种中风危险因素及美国国立卫生研究院卒中量表（NIHSS）评分的数据。回归分析针对中风危险因素等混杂因素进行了调整。
随着饮酒量增加、高血压患病率、心源性栓塞（CE）病因、男性的NIHSS评分以及房颤患病率、其他心脏病、CE和小血管闭塞病因以及女性的NIHSS评分升高，NLR有升高趋势。在对混杂因素进行调整的多元线性回归分析中，男性的房颤和NIHSS评分以及女性的房颤、糖尿病以及NIHSS评分与NLR呈显著正相关。然而，体重指数（BMI）呈负相关。
我们证实房颤可能是急性中风患者高NLR的预测指标之一，而糖尿病以及低BMI可能是女性急性缺血性中风患者高NLR的预测指标。
