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磁共振成像在多发性硬化诊断和治疗监测中的应用指南:瑞典多发性硬化协会和瑞典神经放射学会的建议

Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society.

作者信息

Vågberg M, Axelsson M, Birgander R, Burman J, Cananau C, Forslin Y, Granberg T, Gunnarsson M, von Heijne A, Jönsson L, Karrenbauer V D, Larsson E-M, Lindqvist T, Lycke J, Lönn L, Mentesidou E, Müller S, Nilsson P, Piehl F, Svenningsson A, Vrethem M, Wikström J

机构信息

Department of Pharmacology and Clinical Neuroscience, Section of Neuroscience, Umeå University, Umeå, Sweden.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

出版信息

Acta Neurol Scand. 2017 Jan;135(1):17-24. doi: 10.1111/ane.12667. Epub 2016 Aug 24.

DOI:10.1111/ane.12667
PMID:27558404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5157754/
Abstract

Multiple sclerosis (MS) is associated with inflammatory lesions in the brain and spinal cord. The detection of such inflammatory lesions using magnetic resonance imaging (MRI) is important in the consideration of the diagnosis and differential diagnoses of MS, as well as in the monitoring of disease activity and predicting treatment efficacy. Although there is strong evidence supporting the use of MRI for both the diagnosis and monitoring of disease activity, there is a lack of evidence regarding which MRI protocols to use, the frequency of examinations, and in what clinical situations to consider MRI examination. A national workshop to discuss these issues was held in Stockholm, Sweden, in August 2015, which resulted in a Swedish consensus statement regarding the use of MRI in the care of individuals with MS. The aim of this consensus statement is to provide practical advice for the use of MRI in this setting. The recommendations are based on a review of relevant literature and the clinical experience of workshop attendees. It is our hope that these recommendations will benefit individuals with MS and guide healthcare professionals responsible for their care.

摘要

多发性硬化症(MS)与脑和脊髓的炎性病变相关。利用磁共振成像(MRI)检测此类炎性病变对于MS的诊断、鉴别诊断,以及疾病活动监测和治疗疗效预测均具有重要意义。尽管有强有力的证据支持使用MRI进行疾病诊断和活动监测,但对于使用何种MRI方案、检查频率以及在何种临床情况下考虑进行MRI检查,仍缺乏相关证据。2015年8月在瑞典斯德哥尔摩举行了一次全国性研讨会来讨论这些问题,会议形成了一份关于在MS患者护理中使用MRI的瑞典共识声明。本共识声明的目的是为在这种情况下使用MRI提供实用建议。这些建议基于对相关文献的回顾以及研讨会参会人员的临床经验。我们希望这些建议将使MS患者受益,并指导负责其护理的医疗专业人员。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e8f/5157754/0152321ba7b9/ANE-135-17-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e8f/5157754/0152321ba7b9/ANE-135-17-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e8f/5157754/0152321ba7b9/ANE-135-17-g001.jpg

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Ann Neurol. 2016 Jun;79(6):950-8. doi: 10.1002/ana.24651. Epub 2016 Apr 20.
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一项关于阿仑单抗在真实世界多发性硬化症患者队列中疗效的为期五年的前瞻性单中心观察性研究。
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Intrathecal kappa free light chain synthesis is associated with worse prognosis in relapsing-remitting multiple sclerosis.鞘内κ 游离轻链合成与复发缓解型多发性硬化的预后不良相关。
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The role of autoimmune antibodies to predict secondary autoimmunity in patients with relapsing-remitting multiple sclerosis treated with alemtuzumab: A nationwide prospective survey.自身免疫抗体在预测接受阿仑单抗治疗的复发缓解型多发性硬化患者继发自身免疫中的作用:一项全国性前瞻性调查。
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