临床级人胚胎干细胞系RCe021-A（RC-17）的衍生
Derivation of the clinical grade human embryonic stem cell line RCe021-A (RC-17).
作者信息
De Sousa P A, Tye B J, Bruce K, Dand P, Russell G, Collins D M, Greenshields A, McDonald K, Bradburn H, Allan D, Laurie A, Kunath T, Canham M A, Downie J M, Bateman M, Courtney A
机构信息
Roslin Cells Limited, Nine Edinburgh Bio-Quarter, 9 Little France Road, Edinburgh EH16 4UX, UK; Centre for Clinical Brain Sciences, University of Edinburgh, UK; MRC Centre for Regenerative Medicine, University of Edinburgh, UK.
Roslin Cells Limited, Nine Edinburgh Bio-Quarter, 9 Little France Road, Edinburgh EH16 4UX, UK.
出版信息
Stem Cell Res. 2016 Jul;17(1):1-5. doi: 10.1016/j.scr.2016.04.019. Epub 2016 Apr 30.
The human embryonic stem cell line RCe021-A (RC-17) was derived under quality assured compliance with UK regulation, European Union Directives and International guidance for tissue procurement, processing and storage according to Good Manufacturing Practice (GMP) standards. The cell line was derived from a day 3 embryo voluntarily donated as unsuitable or surplus to fertility requirements following informed consent. RCe021-A (RC-17) shows normal pluripotency marker expression and differentiation to the three germ layers in vitro. It has a normal 46XX female karyotype and microsatellite PCR identity, HLA and blood group typing data are available.
人类胚胎干细胞系RCe021 - A（RC - 17）是在符合英国法规、欧盟指令以及国际组织采购、处理和储存组织的指导方针的质量保证下，按照良好生产规范（GMP）标准衍生而来的。该细胞系源自一个3日龄胚胎，该胚胎在获得知情同意后，因不符合生育要求或多余而自愿捐赠。RCe021 - A（RC - 17）在体外显示出正常的多能性标志物表达，并能分化为三个胚层。它具有正常的46XX女性核型，并且有微卫星PCR身份鉴定、HLA和血型分型数据。
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