Liu Rachel Q, Wiseman Sam M
a Department of Surgery , St. Paul's Hospital and University of British Columbia , Vancouver , British Columbia, Canada.
Expert Rev Anticancer Ther. 2016 Sep;16(9):919-28. doi: 10.1080/14737140.2016.1222274. Epub 2016 Aug 25.
While the disease specific mortality of differentiated thyroid cancer has remained low with current treatments, its incidence has been steadily rising over the past several decades, and cancer related recurrence and morbidity have remained a significant problem. Quality indicators currently employed are relevant to the surgical intervention, but do not necessarily reflect oncological outcomes. Therefore, thyroid cancer specific surgical quality indicators, that offer insight into risk of cancer related morbidity and mortality are needed.
This review aims to discuss the role of measuring quality in thyroid surgical oncology and carry out a comprehensive review of potential quality indicators for thyroid cancer operations. The three quality indicators reviewed here are the postoperative radioactive iodine update by remnant thyroid tissue, the proportion of resected lymph nodes with evidence of metastases, and the post-operative serum thyroglobulin level. Expert commentary: Together, these quality indicators may be utilized to guide improvement of the quality of surgical care for this unique patient population. A critical future step in establishing the role of quality indicators for thyroid cancer surgery is the determination of cutoff values of each indicator in an evidence-based manner.
尽管目前的治疗方法使分化型甲状腺癌的疾病特异性死亡率一直较低,但在过去几十年中其发病率一直在稳步上升,并且癌症相关的复发和发病率仍然是一个重大问题。目前采用的质量指标与手术干预相关,但不一定能反映肿瘤学结果。因此,需要能够洞察癌症相关发病率和死亡率风险的甲状腺癌特异性手术质量指标。
本综述旨在讨论衡量甲状腺外科肿瘤学质量的作用,并对甲状腺癌手术的潜在质量指标进行全面综述。这里审查的三个质量指标是残余甲状腺组织术后放射性碘摄取、有转移证据的切除淋巴结比例以及术后血清甲状腺球蛋白水平。专家评论:这些质量指标共同可用于指导改善针对这一独特患者群体的手术护理质量。以循证方式确定每个指标的临界值是确立甲状腺癌手术质量指标作用的未来关键一步。