Department of Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Front Endocrinol (Lausanne). 2022 Jun 2;13:872527. doi: 10.3389/fendo.2022.872527. eCollection 2022.
Thyroglobulin (Tg) is secreted by thyroid follicular cells and stored in the thyroid follicular lumen as a component of thyroid hormone. It is known that both benign and well-differentiated malignant thyroid tissue can secrete Tg. In recent years, growing lines of evidence have shown that Tg plays an important role in the diagnosis and metastasis of preoperative differentiated thyroid carcinoma (DTC). The levels of Tg, whether in the serum or in a fine-needle aspiration washout fluid, are usually viewed as an excellent indicator in the monitoring of postoperative DTC, including the guidance and evaluation of radioactive iodine ablation. Nevertheless, some factors limit the application of Tg, such as the method used to measure Tg and the presence of Tg antibodies. This review aimed to summarize the role of Tg in the preoperative and postoperative evaluation of patients with DTC, and the factors influencing Tg. This review could provide a reference for a more accurate application of Tg in patients with DTC.
甲状腺球蛋白（Tg）由甲状腺滤泡细胞分泌，作为甲状腺激素的成分储存在甲状腺滤泡腔中。已知良性和分化良好的恶性甲状腺组织均可分泌 Tg。近年来，越来越多的证据表明 Tg 在术前分化型甲状腺癌（DTC）的诊断和转移中发挥重要作用。Tg 的水平，无论是在血清中还是在细针抽吸洗脱液中，通常被视为监测术后 DTC 的一个极好指标，包括放射性碘消融的指导和评估。然而，一些因素限制了 Tg 的应用，如 Tg 的测量方法和 Tg 抗体的存在。本综述旨在总结 Tg 在 DTC 患者术前和术后评估中的作用以及影响 Tg 的因素。本综述可为更准确地应用 Tg 于 DTC 患者提供参考。
