Cameron Robert B, Beeson Craig C, Schnellmann Rick G
Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina , 280 Calhoun Street, Charleston, South Carolina 29425, United States.
College of Pharmacy, University of Arizona , 1295 N. Martin Avenue, Tucson, Arizona 85721, United States.
J Med Chem. 2016 Dec 8;59(23):10411-10434. doi: 10.1021/acs.jmedchem.6b00669. Epub 2016 Sep 27.
Mitochondria have various roles in cellular metabolism and homeostasis. Because mitochondrial dysfunction is associated with many acute and chronic degenerative diseases, mitochondrial biogenesis (MB) is a therapeutic target for treating such diseases. Here, we review the role of mitochondrial dysfunction in acute and chronic degenerative diseases and the cellular signaling pathways by which MB is induced. We then review existing work describing the development and application of drugs that induce MB in vitro and in vivo. In particular, we discuss natural products and modulators of transcription factors, kinases, cyclic nucleotides, and G protein-coupled receptors.
线粒体在细胞代谢和内环境稳态中发挥着多种作用。由于线粒体功能障碍与许多急性和慢性退行性疾病相关，线粒体生物合成（MB）是治疗此类疾病的一个治疗靶点。在此，我们综述线粒体功能障碍在急性和慢性退行性疾病中的作用以及诱导MB的细胞信号通路。然后，我们综述了描述在体外和体内诱导MB的药物的开发和应用的现有研究。特别地，我们讨论了天然产物以及转录因子、激酶、环核苷酸和G蛋白偶联受体的调节剂。
