Minoretti Piercarlo, Emanuele Enzo
Occupational Medicine, Studio Minoretti, Oggiono, ITA.
Clinical Pathology, 2E Science, Robbio, ITA.
Cureus. 2024 Jan 19;16(1):e52548. doi: 10.7759/cureus.52548. eCollection 2024 Jan.
In this narrative review, we sought to provide a comprehensive overview of the mechanisms underlying cutaneous senescence, framed by the twelve traditional hallmarks of aging. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. We also examined how topical interventions targeting these hallmarks can be integrated with conventional aesthetic medicine techniques to enhance skin rejuvenation. The potential of combining targeted topical therapies against the aging hallmarks with minimally invasive procedures represents a significant advancement in aesthetic medicine, offering personalized and effective strategies to combat skin aging. The reviewed evidence paves the way for future advancements and underscores the transformative potential of integrating scientifically validated interventions targeted against aging hallmarks into traditional aesthetic practices.
在这篇叙述性综述中，我们试图以衰老的十二个传统特征为框架，全面概述皮肤衰老的潜在机制。这些特征包括基因组不稳定、端粒磨损、表观遗传改变、蛋白质稳态丧失、巨自噬受损、营养感应失调、线粒体功能障碍、细胞衰老、干细胞耗竭、细胞间通讯改变、慢性炎症和微生物群失调。我们还研究了针对这些特征的局部干预措施如何与传统美容医学技术相结合，以促进皮肤年轻化。将针对衰老特征的靶向局部治疗与微创程序相结合的潜力代表了美容医学的重大进展，为对抗皮肤衰老提供了个性化且有效的策略。所综述的证据为未来的进展铺平了道路，并强调了将针对衰老特征的经过科学验证的干预措施整合到传统美容实践中的变革潜力。
