Akter Kaisarun, Barnes Emma C, Brophy Joseph J, Harrington David, Community Elders Yaegl, Vemulpad Subramanyam R, Jamie Joanne F
Indigenous Bioresources Research Group, Faculty of Science and Engineering, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
School of Chemistry, Faculty of Science, University of New South Wales, Sydney, NSW 2052, Australia.
Evid Based Complement Alternat Med. 2016;2016:4683059. doi: 10.1155/2016/4683059. Epub 2016 Aug 2.
Aboriginal people of Australia possess a rich knowledge on the use of medicinal plants for the treatment of sores, wounds, and skin infections, ailments which impose a high global disease burden and require effective treatments. The antibacterial and antioxidant activities and phytochemical contents of extracts, obtained from eight medicinal plants used by Aboriginal people of New South Wales, Australia, for the treatment of skin related ailments, were assessed to add value to and provide an evidence-base for their traditional uses. Extracts of Acacia implexa, Acacia falcata, Cassytha glabella, Eucalyptus haemastoma, Smilax glyciphylla, Sterculia quadrifida, and Syncarpia glomulifera were evaluated. All extracts except that of S. quadrifida showed activity against sensitive and multidrug resistant strains of Staphylococcus aureus with minimum inhibitory concentration values ranging from 7.81 to 1000 μg/mL. The sap of E. haemastoma and bark of A. implexa possessed high total phenolic contents (TPC) and strong DPPH radical scavenging abilities. A positive correlation was observed between TPC and free radical scavenging ability. GC-MS analysis of the n-hexane extract of S. glomulifera identified known antimicrobial compounds. Together, these results support the traditional uses of the examined plants for the treatment of skin related ailments and infections by Aboriginal people of New South Wales, Australia.
澳大利亚原住民拥有丰富的药用植物知识，用于治疗溃疡、伤口和皮肤感染，这些疾病在全球疾病负担中占比很高，需要有效的治疗方法。对从澳大利亚新南威尔士州原住民用于治疗皮肤相关疾病的八种药用植物中提取的提取物的抗菌和抗氧化活性以及植物化学成分进行了评估，以提升其传统用途的价值并提供证据基础。对柔叶金合欢、镰叶相思、无根藤、血红桉、光叶菝葜、四裂苹婆和团花树的提取物进行了评估。除四裂苹婆提取物外，所有提取物均对金黄色葡萄球菌的敏感菌株和多重耐药菌株显示出活性，最低抑菌浓度值范围为7.81至1000μg/mL。血红桉的汁液和柔叶金合欢的树皮具有较高的总酚含量（TPC）和较强的DPPH自由基清除能力。观察到TPC与自由基清除能力之间存在正相关。对团花树正己烷提取物的GC-MS分析鉴定出了已知的抗菌化合物。这些结果共同支持了澳大利亚新南威尔士州原住民将所研究的植物用于治疗皮肤相关疾病和感染的传统用途。
