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儿童使用Glubran(®) 2进行包皮环切术:意大利中心的经验。

Circumcision with Glubran(®) 2 in children: experience of Italian Center.

作者信息

Angotti Rossella, Cerchia Elisa, Molinaro Francesco, Bulotta Anna Lavinia, Ferrara Francesco, Bindi Edoardo, Messina Mario

机构信息

Division of Pediatric Surgery, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

出版信息

Gland Surg. 2016 Aug;5(4):391-7. doi: 10.21037/gs.2016.03.03.

Abstract

BACKGROUND

Circumcision is one of the most common surgical procedures in the world. Despite it is known its wide prevalence for religious and medical reasons in children, it remains a controversial practice in paediatric age. To date, there is no described the gold standard technique to circumcise paediatric patients. We started to use glue for circumcision about 2 years ago. We designed this prospective study with the aim to compare two surgical techniques, which were used in our hospital to perform circumcision in children. The implication for practice was the understanding if there were differences between these approaches related to patient's and parents benefits to manage this condition and benefits for surgeon and hospital in term of saving money and time.

METHODS

This is a randomized, single-blind one-center study. It was conducted at the Department of Paediatric Surgery of Siena. Data were collected between March 2011 and December 2012. Study's population involved all patients who required circumcision. Two randomizes groups: group one which involved patients who underwent circumcision using sutures and group two, which involved patients who underwent circumcision using surgical glue (Glubran(®) 2). Two exclusion criteria were used: the redo-circumcision and the allergy or hyper-sensibility to cyanoacrylate (main component of glue).

RESULTS

We report 99 patients who underwent circumcision with Glubran(®) 2 in comparison with a group of children circumcised with sutures (vycril rapide). We measured three outcomes (operating time, postoperative pain and assessment of cosmetic), which, even if not all statistically significant, allowed us to draw any conclusions about the use of glue in circumcision.

CONCLUSIONS

Traditional circumcision is performed using a standard sleeve technique with sutures for the approximation of the skin edges. However, since some years a tissue adhesive as N-butyl-2-cyanoacrylate (NBCA) (Glubran(®) 2) is used in many centers to circumcise children. Based on our results we can conclude that, glue (Glubran(®) 2) application is an excellent alternative to circumcision in paediatric age for a faster surgery, less postoperative pain and good early cosmetic.

摘要

背景

包皮环切术是世界上最常见的外科手术之一。尽管因宗教和医学原因,其在儿童中的广泛普及众所周知,但在儿科年龄段,它仍然是一种存在争议的做法。迄今为止,尚未有描述用于小儿患者包皮环切术的金标准技术。大约两年前,我们开始使用胶水进行包皮环切术。我们设计了这项前瞻性研究,旨在比较我院用于儿童包皮环切术的两种手术技术。实践中的意义在于了解这些方法在患者和家长管理这种情况的益处以及对外科医生和医院在节省金钱和时间方面的益处之间是否存在差异。

方法

这是一项随机、单盲的单中心研究。在锡耶纳儿科外科进行。数据收集于2011年3月至2012年12月之间。研究人群包括所有需要进行包皮环切术的患者。分为两个随机组:第一组包括使用缝线进行包皮环切术的患者,第二组包括使用外科胶水(Glubran(®) 2)进行包皮环切术的患者。使用了两个排除标准:再次包皮环切术以及对氰基丙烯酸酯(胶水的主要成分)过敏或超敏反应。

结果

我们报告了99例使用Glubran(®) 2进行包皮环切术的患者,并与一组使用缝线(vycril rapide)进行包皮环切术的儿童进行了比较。我们测量了三个结果(手术时间、术后疼痛和外观评估),即使并非所有结果都具有统计学意义,但仍使我们能够就胶水在包皮环切术中的使用得出任何结论。

结论

传统的包皮环切术采用标准的袖套技术,用缝线来使皮肤边缘对合。然而,多年来,一种组织粘合剂如正丁基-2-氰基丙烯酸酯(NBCA)(Glubran(®) 2)在许多中心被用于儿童包皮环切术。基于我们的结果,我们可以得出结论,在儿科年龄段,应用胶水(Glubran(®) 2)进行包皮环切术是一种极佳的替代方法,手术更快、术后疼痛更少且早期外观良好。

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