Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Biomed Res Int. 2017;2017:7464872. doi: 10.1155/2017/7464872. Epub 2017 Sep 19.
Icariin (ICA), a prenylated flavanol glycoside present in abundant quantities in , has shown promise in the treatment and prevention of Alzheimer's disease. Damage to synaptic plasticity induced by amyloid-beta-mediated neurotoxicity is considered a main pathological mechanism driving the learning and memory deficits present in patients with Alzheimer's disease. This study investigated the neuroprotective effects of icariin in an A-induced rat model of Alzheimer's disease. Our results showed that A injection induced loss of learning and memory behaviour in the Morris water maze, which could be reversed with intragastric administration of ICA. Furthermore, ICA reversed decreases in PSD-95, BDNF, pTrkB, pAkt, and pCREB expressions and prevented deterioration of synaptic interface structure. These findings indicate that ICA may improve synaptic plasticity through the BDNF/TrkB/Akt pathway and provide further evidence for its clinical application to improve learning and memory in patients with Alzheimer's disease.
淫羊藿苷（ICA）是一种在 中大量存在的苯丙素类黄酮糖苷，在阿尔茨海默病的治疗和预防方面显示出了良好的效果。由淀粉样蛋白-β介导的神经毒性引起的突触可塑性损伤被认为是导致阿尔茨海默病患者学习和记忆缺陷的主要病理机制。本研究探讨了淫羊藿苷在阿尔茨海默病 A 诱导大鼠模型中的神经保护作用。我们的研究结果表明，A 注射诱导 Morris 水迷宫中学习和记忆行为的丧失，而 ICA 的胃内给药可以逆转这种情况。此外，ICA 逆转了 PSD-95、BDNF、pTrkB、pAkt 和 pCREB 表达的降低，并防止了突触界面结构的恶化。这些发现表明，ICA 可能通过 BDNF/TrkB/Akt 通路改善突触可塑性，并为其在改善阿尔茨海默病患者学习和记忆方面的临床应用提供了进一步的证据。
