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基于网络药理学的治疗阿尔茨海默病作用机制研究。

Network pharmacology-based study on the mechanism of for treating Alzheimer's disease.

机构信息

Department of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shangxi, China.

School of Life Science, Beijing Institute of Technology, Beijing, China.

出版信息

Indian J Pharmacol. 2020 Mar-Apr;52(2):94-101. doi: 10.4103/ijp.IJP_515_19. Epub 2020 Jun 3.

DOI:10.4103/ijp.IJP_515_19
PMID:32565596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7282681/
Abstract

BACKGROUND

Alzheimer's disease (AD) is a mental illness that poses a serious threat to human health worldwide. is a natural herb that can treat the effects of AD, but its specific mechanism is still unclear. The purpose of this study was to explore the potential components and pharmacological pathways of in the treatment of AD.

MATERIALS AND METHODS

In this study, we investigated the compound of and the effects of it on AD by network pharmacology. Meanwhile, the potential mechanism was proved .

RESULTS

The results showed that contained 173 compounds. Compound-target network confirmed that (E)-9-Isopropyl-6-Methyl-5,9-Decadiene-2-One, 1-Phenyl-1,3-Butanedion, nootkatone and phenyl-2-Propanone were the main chemical constituents which highly aimed at APOE, CACNA1D, GRIN2A, and PTGS2. KEGG and GO enrichment analysis indicated that the main pathways involved neural-related signaling pathways and functions, such as nicotine addiction, GABAergic synapse, Ca signaling pathway, AD, and so on. Validation experiments showed that nootkatone was able to exert anti-apoptotic effects related to Ca signaling pathway by inhibiting nitric oxide production, enhancing the activity of antioxidant enzymes, upregulating the expression of anti-oxidation and anti-apoptotic proteins .

CONCLUSIONS

These results illustrated that could regulate neuronal apoptosis through the calcium signaling pathway to exert anti-AD by integrating multi-component, multi-target and multi-pathway.

摘要

背景

阿尔茨海默病（AD）是一种精神疾病，对全球人类健康构成严重威胁。益智仁是一种天然草药，可以治疗 AD 的影响，但具体机制尚不清楚。本研究旨在探讨益智仁治疗 AD 的潜在成分和药理学途径。

材料和方法

在这项研究中，我们通过网络药理学研究了益智仁的化合物及其对 AD 的影响。同时，对潜在机制进行了验证。

结果

结果表明，益智仁含有 173 种化合物。化合物-靶标网络证实（E）-9-异丙基-6-甲基-5,9-癸二烯-2-酮、1-苯基-1,3-丁二酮、nootkatone 和苯-2-丙酮是针对 APOE、CACNA1D、GRIN2A 和 PTGS2 的主要化学物质。KEGG 和 GO 富集分析表明，主要途径涉及神经相关信号通路和功能，如尼古丁成瘾、GABA 能突触、Ca 信号通路、AD 等。验证实验表明，nootkatone 能够通过抑制一氧化氮产生、增强抗氧化酶活性、上调抗氧化和抗凋亡蛋白的表达，发挥与 Ca 信号通路相关的抗凋亡作用。

结论

这些结果表明，益智仁可以通过钙信号通路调节神经元凋亡，通过整合多成分、多靶点和多途径发挥抗 AD 作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/7e955d1bf5cc/IJPharm-52-94-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/1fcd5a324253/IJPharm-52-94-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/f36e6fe5dce7/IJPharm-52-94-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/406bbe38b863/IJPharm-52-94-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/a8aab714d85e/IJPharm-52-94-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/ed5823a150b5/IJPharm-52-94-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/7e955d1bf5cc/IJPharm-52-94-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/1fcd5a324253/IJPharm-52-94-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/f36e6fe5dce7/IJPharm-52-94-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/406bbe38b863/IJPharm-52-94-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/a8aab714d85e/IJPharm-52-94-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/ed5823a150b5/IJPharm-52-94-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6cc/7282681/7e955d1bf5cc/IJPharm-52-94-g006.jpg

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