天然β-咔啉类海鞘素U的DNA结合研究
DNA-binding studies of the natural β-carboline eudistomin U.
作者信息
Giulietti Jennifer M, Tate Patrick M, Cai Ang, Cho Bongsup, Mulcahy Seann P
机构信息
Providence College, Department of Chemistry and Biochemistry, 1 Cunningham Square, Providence, RI 02918, USA.
University of Rhode Island, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, 7 Greenhouse Road, Kingston, RI 02881, USA.
出版信息
Bioorg Med Chem Lett. 2016 Oct 1;26(19):4705-4708. doi: 10.1016/j.bmcl.2016.08.047. Epub 2016 Aug 18.
Abstract
Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV-Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class.
摘要
优地斯明U是含杂环胺的β-咔啉类分子的一员，这类分子能够与DNA结合。优地斯明U的结构独特，因为它在吡啶环的1位含有一个吲哚环。虽然据报道简单的β-咔啉能嵌入DNA，但对优地斯明U的结合模式的研究尚缺。我们报告了关于优地斯明U与DNA结合的初步光谱（紫外可见光谱、热变性、圆二色光谱）和量热（差示扫描量热法）数据，这些数据表明优地斯明U以一种比其同类其他成员更复杂的机制弱结合。
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