癌症中的核纤层蛋白。
Nuclear lamins in cancer.
作者信息
Irianto Jerome, Pfeifer Charlotte R, Ivanovska Irena L, Swift Joe, Discher Dennis E
机构信息
Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Cell Mol Bioeng. 2016 Jun;9(2):258-267. doi: 10.1007/s12195-016-0437-8. Epub 2016 Apr 18.
Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating cancer progression to lamina biophysics. Lamin levels can constrain cancer cell migration in 3D and thereby impede tumor growth, and lamins can also protect a cancer cell's genome. In addition, lamins can influence transcriptional regulators (RAR, SRF, YAP/TAZ) and chromosome conformation in lamina associated domains. Further investigation of the roles for lamins in cancer and even DNA damage may lead to new therapies or at least to a clearer understanding of lamins as bio-markers in cancer progression.
异形细胞核在癌症中很常见，这为研究细胞核的主要结构蛋白——核纤层蛋白在癌症中的作用提供了强大的动力。过去的研究也证明了微环境力学对癌症进展的重要性，这非常有趣，因为最近发现核纤层对力学敏感。在这里，我们回顾了目前将癌症进展与核纤层生物物理学相关联的知识。核纤层蛋白水平可以限制癌细胞在三维空间中的迁移，从而阻碍肿瘤生长，并且核纤层蛋白还可以保护癌细胞的基因组。此外，核纤层蛋白可以影响层粘连相关结构域中的转录调节因子（视黄酸受体、血清反应因子、Yes相关蛋白/具有PDZ结合基序的转录共激活因子）和染色体构象。进一步研究核纤层蛋白在癌症甚至DNA损伤中的作用，可能会带来新的治疗方法，或者至少能更清楚地了解核纤层蛋白作为癌症进展生物标志物的情况。
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