Pietra Marco, Zanoni Renato Giulio, Peli Angelo, Brunetti Barbara, Linta Nikolina, Capitani Ombretta, Spinella Giuseppe
Department of Veterinary Medical Sciences, School of Agriculture and Veterinary Medicine, Alma Mater Studiorum - University of Bologna, Ozzano dell'Emilia (BO), 40064 Italy.
Ir Vet J. 2016 Aug 26;69(1):12. doi: 10.1186/s13620-016-0071-8. eCollection 2015.
The authors report the first case of feline gastric actinomycosis associated with infection by Actinomyces hordeovulneris.
A 4-year-old, neutered male, semi-feral European cat, with a 1 year history of chronic vomiting, was referred to the clinic. Abdominal ultrasound examination identified a hypoechoic focal transmural thickening with loss of normal wall layering and hyperechoic speckles at the gastric body. Initial gastroscopic examination showed a tumour-like gastric mass with an ulcerated depression at the level of the greater curvature. Histologic examination of endoscopic biopsy specimens was consistent with a severe lymphoplasmacytic gastritis. After 2 months, due to persistence of abdominal discomfort, surgical exploration and intraoperative sampling of gross abnormalities was recommended. Full thickness gastric wall biopsies, and fine needle aspiration of the gastric thickening and gastric lymph node, were performed. Histopathological examination identified a transmural pyogranulomatous gastritis. Aspirate samples of the gastric wall cultured positive, with colony morphology, biochemical testing and PCR of the 16 s rRNA gene compatible with Actinomyces hordeovulneris. After 4 months of treatment with cefovecin (8 mg/kg subcutaneously every 14 days), the vomiting completely resolved, as well as the ultrasonographic gastric alteration.
This case report of feline gastric actinomycosis, caused by Actinomyces hordeovulneris, suggests that gastric bacterial infection should be considered in cases of focal gastric wall thickening associated with chronic vomiting in the cat, which may otherwise closely resemble neoplastic disease. Once a diagnosis of actinomycosis was obtained, a correct treatment with antibiotic therapy can resolve it.
作者报告了首例与脆弱放线菌感染相关的猫胃放线菌病病例。
一只4岁已绝育的半野生欧洲雄性猫，有1年慢性呕吐病史，被转诊至诊所。腹部超声检查发现胃体部有低回声局灶性透壁增厚，正常壁层结构消失，伴有高回声斑点。初次胃镜检查显示胃大弯处有一个肿瘤样胃肿物，伴有溃疡凹陷。内镜活检标本的组织学检查结果符合重度淋巴细胞性胃炎。2个月后，由于腹部不适持续存在，建议进行手术探查并对肉眼可见的异常进行术中取样。进行了胃壁全层活检以及对胃增厚处和胃淋巴结的细针穿刺抽吸。组织病理学检查发现透壁性脓性肉芽肿性胃炎。胃壁抽吸样本培养呈阳性，菌落形态、生化检测以及16s rRNA基因的PCR检测结果均与脆弱放线菌相符。在用头孢维星（每14天皮下注射8mg/kg）治疗4个月后，呕吐完全缓解，胃超声改变也消失。
这例由脆弱放线菌引起的猫胃放线菌病病例报告表明，对于猫出现与慢性呕吐相关的局灶性胃壁增厚情况，应考虑胃细菌感染，否则可能与肿瘤性疾病极为相似。一旦确诊为放线菌病，使用抗生素进行正确治疗可使其痊愈。
