Lee Jae Jin, Kim Mi-Na, Park Kwang Seung, Lee Jung Hun, Karim Asad Mustafa, Park Moonhee, Kim Ji Hwan, Lee Sang Hee
National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea.
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6937-6940. doi: 10.1128/AAC.00614-16. Print 2016 Nov.
The coexistence of qnrB62 and bla was detected in a Citrobacter clinical isolate. The reduced fluoroquinolone susceptibility is attributable to qnrB62, mutations of quinolone-resistance-determining regions, and an efflux pump or pumps. The genetic context surrounding chromosomal qnrB62 was a novel complex class 1 integron (In1184::ISCR1::qnrB62) containing a unique gene array (bla-aacA4'-8-gucD). An 18-nucleotide deletion at the 3' end of the pspA gene [pspA(Δ18)], upstream of qnrB62, and an inverted repeat region (IRR2) were detected in In1184::ISCR1::qnrB62, indicating past transposition events.
在一株柠檬酸杆菌临床分离株中检测到qnrB62和bla共存。氟喹诺酮敏感性降低归因于qnrB62、喹诺酮抗性决定区的突变以及一个或多个外排泵。染色体qnrB62周围的遗传背景是一个新型复合1类整合子(In1184::ISCR1::qnrB62),包含一个独特的基因阵列(bla-aacA4'-8-gucD)。在In1184::ISCR1::qnrB62中检测到qnrB62上游pspA基因3'端的18个核苷酸缺失[pspA(Δ18)]和一个反向重复区域(IRR2),表明过去发生过转座事件。