Adams D H, Clark R A, Davies M J, de Lacey S
1School of Nursing and Midwifery,Flinders University,Bedford Park,SA,Australia.
2Robinson Institute,The University of Adelaide,Adelaide,SA,Australia.
J Dev Orig Health Dis. 2017 Feb;8(1):44-55. doi: 10.1017/S2040174416000489. Epub 2016 Aug 30.
Although the use of donor sperm as a treatment modality for male infertility has become common place, the health outcomes for those conceived has been poorly studied. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the health outcomes of offspring conceived from donor sperm. Eight studies were eligible and included in the review, and of these, three were included in a meta-analysis. Meta-analysis of clinical outcomes showed that donor sperm neonates are not at increased risk of being born of low birth weight (<2500 g), preterm (<37 weeks) or with increased incidences of birth defects, than spontaneously conceived neonates.
尽管使用供体精子作为男性不育的一种治疗方式已变得很常见，但对于那些通过这种方式受孕者的健康结局却鲜有研究。我们利用PubMed、EMBASE和Cochrane综述对文献进行了系统检索，以调查供体精子受孕后代的健康结局。有八项研究符合纳入标准并被纳入该综述，其中三项被纳入荟萃分析。临床结局的荟萃分析表明，与自然受孕的新生儿相比，供体精子受孕的新生儿出生时低体重（<2500克）、早产（<37周）或出生缺陷发生率增加的风险并未升高。
