McMahon James E, Graves Jessica L, Tovar Ashley P, Peloquin Matthew, Greenwood Karen, Chen Frances L, Nelson Michelle, McCandless Erin E, Halioua-Haubold Celine-Lea, Juarez-Salinas Dina
Cellular Longevity Inc., San Francisco, CA, USA.
Sci Rep. 2025 Apr 25;15(1):14460. doi: 10.1038/s41598-025-99349-2.
Dogs serve as a promising aging model due to their genetic diversity, condensed lifespan, and shared living environment with humans. Alterations in the immune and metabolic parameters are hallmarks of aging in humans, but few studies have investigated these changes in dogs. We investigated the association of whole blood parameters with aging in a cross-sectional field study with a population of 451 companion dogs. Additionally, we measured total lymphocytes, total T-cells, CD4 T-cells, CD8 T-cells, B-cells, CBC, insulin and adiponectin in a cross-sectional study of 74 laboratory research beagles. In companion dogs, we report total lymphocytes and RBCs decrease significantly with age while platelets increase significantly. In lab beagles, total lymphocytes, T-cells, CD4 T-cells, CD8 T-cells, and B cells are significantly lower in Aged and Geriatric beagles. Furthermore, the CD4/CD8 ratio is significantly lower in Geriatric beagles. We also found that Geriatric beagles experience hyperinsulinemia, while plasma adiponectin is significantly lower in both Aged and Geriatric beagles. These results align with the age-related immune and metabolic alterations seen in humans and provide additional evidence that dogs serve as a relevant translational model of aging.
由于狗具有遗传多样性、寿命缩短以及与人类共享生活环境，它们是一种很有前景的衰老模型。免疫和代谢参数的改变是人类衰老的标志，但很少有研究调查狗的这些变化。在一项对451只宠物狗的横断面现场研究中，我们调查了全血参数与衰老的关联。此外，在一项对74只实验用比格犬的横断面研究中，我们测量了总淋巴细胞、总T细胞、CD4 T细胞、CD8 T细胞、B细胞、全血细胞计数、胰岛素和脂联素。在宠物狗中，我们发现总淋巴细胞和红细胞随年龄显著减少，而血小板显著增加。在实验用比格犬中，老年和高龄比格犬的总淋巴细胞、T细胞、CD4 T细胞、CD8 T细胞和B细胞显著减少。此外，高龄比格犬的CD4/CD8比值显著降低。我们还发现高龄比格犬存在高胰岛素血症，而老年和高龄比格犬的血浆脂联素均显著降低。这些结果与在人类中观察到的与年龄相关的免疫和代谢改变一致，并提供了额外的证据，证明狗是一种相关的衰老转化模型。
