2001年至2014年非洲、亚洲和南美洲志贺氏菌属血清多样性及抗菌药物耐药模式综述
A review on Sero diversity and antimicrobial resistance patterns of Shigella species in Africa, Asia and South America, 2001-2014.
作者信息
Kahsay Atsebaha Gebrekidan, Muthupandian Saravanan
机构信息
Department of Medical Microbiology and Immunology, Institute of Biomedical Sciences, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia.
出版信息
BMC Res Notes. 2016 Aug 30;9(1):422. doi: 10.1186/s13104-016-2236-7.
BACKGROUND
Shigella, gram negative bacterium, is responsible for Shigellosis/bacillary dysentery. It is a global concern although it predominates in developing countries. These are Shigella dysenteriae, Shigella flexneri, Shigella boydii and Shigella sonnei. Drug resistance by Shigella species is another headache of the world. Therefore; this study aimed to review distribution of Shigella Serogroups and their antimicrobial patterns carried out in Africa, Asia and South America.
METHODS
A literature search was performed to identify published studies between January 2001 and December 2014. Published studies were identified using an initial search of the MEDLINE/Index Medicus Database, PubMed, Project Management Consultant, Google Scholar, Science Direct, BioMed Central and Index Copernicus.
RESULTS
Shigella flexneri was isolated predominately from seven studies in four African countries and eight studies in five Asian countries. The countries in which eligible studies carried out were Ethiopia, Kenya, Eritrea and Ghana in Africa and Pakistan, Iran, China, Nepal and India in Asia. S. sonnei was isolated predominately from one study in Africa, four in Asia and two South America. The countries in which eligible studies carried out were Ethiopia from Africa, Thailand, Vietnam and Iran from Asia and Chile and Trinidad from South America. S. dysentery was also reported majorly from one eligible study in Egypt and one in Nepal. S. boydii did not score highest prevalence in any one of the eligible studies. Three studies from Africa, five from Asia and one from South America were reviewed for antimicrobial resistance patterns of Shigella Serogroups. In all the regions, Ampicillin developed highly resistance to almost all the Serogroups of Shigella whereas all the strains were sensitive to Ciprofloxacin.
CONCLUSION
The incidence of Shigella Serogroups in the selected three regions is different. The domination of S. flexneri is observed in Africa and Asia although S. sonnei in South America is dominant. Shigella Serogroups are becoming resistance to the commonly prescribed antimicrobial drugs in developing countries.
背景
志贺氏菌属革兰氏阴性菌，是导致志贺氏菌病/细菌性痢疾的病原体。尽管在发展中国家更为常见，但它仍是一个全球性问题。志贺氏菌属包括痢疾志贺氏菌、福氏志贺氏菌、鲍氏志贺氏菌和宋内志贺氏菌。志贺氏菌属的耐药性是另一个全球性难题。因此，本研究旨在综述在非洲、亚洲和南美洲开展的关于志贺氏菌血清群分布及其抗菌模式的研究。
方法
进行文献检索，以确定2001年1月至2014年12月期间发表的研究。通过初步检索MEDLINE/医学索引数据库、PubMed、项目管理顾问、谷歌学术、科学Direct、BioMed Central和哥白尼索引来识别已发表的研究。
结果
福氏志贺氏菌主要从非洲四个国家的七项研究和亚洲五个国家的八项研究中分离得到。开展符合条件研究的国家在非洲有埃塞俄比亚、肯尼亚、厄立特里亚和加纳，在亚洲有巴基斯坦、伊朗、中国、尼泊尔和印度。宋内志贺氏菌主要从非洲的一项研究、亚洲的四项研究和南美洲的两项研究中分离得到。开展符合条件研究的国家在非洲是埃塞俄比亚，在亚洲是泰国、越南和伊朗，在南美洲是智利和特立尼达。痢疾志贺氏菌也主要从埃及的一项符合条件研究和尼泊尔的一项研究中报道。鲍氏志贺氏菌在任何一项符合条件的研究中都未达到最高流行率。对来自非洲的三项研究、亚洲的五项研究和南美洲的一项研究进行了志贺氏菌血清群抗菌耐药模式的综述。在所有地区，氨苄青霉素对几乎所有志贺氏菌血清群都产生了高度耐药性，而所有菌株对环丙沙星敏感。
结论
所选三个地区志贺氏菌血清群的发病率不同。在非洲和亚洲观察到福氏志贺氏菌占主导地位，而在南美洲宋内志贺氏菌占主导地位。志贺氏菌血清群对发展中国家常用的抗菌药物正产生耐药性。
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