儿童感染志贺菌相关腹泻与抗菌药物敏感性。
Diarrhea associated with Shigella in children and susceptibility to antimicrobials.
机构信息
Departamento de Parasitologia e Microbiologia, Centro de Ciências da Saúde, Universidade Federal do Piauí, Teresina, PI, Brazil.
出版信息
J Pediatr (Rio J). 2012 Mar-Apr;88(2):125-8. doi: 10.2223/JPED.2131. Epub 2011 Nov 16.
OBJECTIVE
To evaluate the distribution and susceptibility to antimicrobials of Shigella isolated from children with acute diarrhea and without diarrhea in Teresina, state of Piauí, Brazil.
METHODS
Four hundred children aged up to 60 months were studied. Stools were collected from all the patients between January 2004 and August 2007. Shigella was identified by conventional methods and antibiogram and extended-spectrum beta-lactamase (ESBL) were performed by agar diffusion.
RESULTS
Shigellosis was only detected in children with acute diarrhea (26/250; 10.4%), especially in those aged from 6 to 24 months and in the rainy months. Shigella was susceptible to ceftriaxone, ciprofloxacin and nalidixic acid. More than half of the strains were resistant to sulphametoxazole-trimethoprim and ampicillin. ESBL was not detected.
CONCLUSIONS
S. flexneri is common in Teresina. The resistance to ampicillin and sulphametoxazole-trimethoprim gives cause for concern, as these drugs are widely used in practice and sulphametoxazole-trimethoprim is also recommended for treating children suspected of having shigellosis.
目的
评估巴西皮奥伊州特雷西纳市急性腹泻和非腹泻儿童分离的志贺菌的分布和药敏情况。
方法
研究纳入了 400 名年龄在 60 个月以下的儿童。2004 年 1 月至 2007 年 8 月期间，所有患者均采集粪便。采用常规方法鉴定志贺菌，并通过琼脂扩散法进行抗生素谱和超广谱β-内酰胺酶（ESBL）检测。
结果
志贺菌病仅在急性腹泻儿童（26/250；10.4%）中检出，尤其是 6 至 24 个月大的儿童和雨季。志贺菌对头孢曲松、环丙沙星和萘啶酸敏感。超过一半的菌株对磺胺甲噁唑-甲氧苄啶和氨苄西林耐药。未检出 ESBL。
结论
福氏志贺菌在特雷西纳市较为常见。对氨苄西林和磺胺甲噁唑-甲氧苄啶的耐药性令人担忧，因为这些药物在实践中广泛使用，磺胺甲噁唑-甲氧苄啶也被推荐用于治疗疑似患有志贺菌病的儿童。
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