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间歇性而非持续性乙醇暴露后突触体酸性磷脂增加。

Increase in synaptosomal acidic phospholipids after intermittent but not continuous ethanol exposure.

作者信息

Gustavsson L, Alling C

机构信息

Department of Psychiatry and Neurochemistry, Lund University, Sweden.

出版信息

Alcohol Alcohol. 1989;24(3):193-6.

PMID:2757697
Abstract

The aim of this study was to compare the effects of different ethanol administration procedures on synaptosomal concentrations of acidic phospholipids. The concentrations of phosphatidylinositol and phosphatidylserine were significantly increased after intermittent ethanol exposure for one week but were unaltered after one or three weeks of continuous ethanol administration. The results indicate the importance of drinking pattern for changes in synaptosomal acidic phospholipids.

摘要

本研究的目的是比较不同乙醇给药程序对突触体酸性磷脂浓度的影响。间歇性乙醇暴露一周后,磷脂酰肌醇和磷脂酰丝氨酸的浓度显著增加,但连续乙醇给药一周或三周后,其浓度未发生改变。结果表明饮酒模式对突触体酸性磷脂变化的重要性。

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Increase in synaptosomal acidic phospholipids after intermittent but not continuous ethanol exposure.间歇性而非持续性乙醇暴露后突触体酸性磷脂增加。
Alcohol Alcohol. 1989;24(3):193-6.
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引用本文的文献

1
Metabolism and functions of phosphatidylserine in mammalian brain.磷脂酰丝氨酸在哺乳动物大脑中的代谢与功能
Neurochem Res. 2003 Feb;28(2):195-214. doi: 10.1023/a:1022412831330.
2
Ethanol potentiates the uptake of [14C]serine into phosphatidylserine by base-exchange reaction in NG 108-15 cells.乙醇通过碱基交换反应增强NG 108 - 15细胞中[14C]丝氨酸向磷脂酰丝氨酸的摄取。
Neurochem Res. 1996 Mar;21(3):305-11. doi: 10.1007/BF02531645.
3
Long-term effects of intermittent versus continuous ethanol exposure on hippocampal synapses of the rat.
间歇性与持续性乙醇暴露对大鼠海马突触的长期影响。
Acta Neuropathol. 1994;87(3):242-9. doi: 10.1007/BF00296739.