Trzeciak H I, Herman Z S, Kryk A, Kryk K
Arch Immunol Ther Exp (Warsz). 1979;27(3):325-8.
6-hydroxydopamine and 6-hydroxydopa injected intraperitoneally in dose of 50 microgram/g in newborn rats, two and six weeks old caused a drop in content of phosphatidylcholine and phosphatidylserine, and an increase in content of phosphatidylinositol in the brains of two weeks old rats treated with 6-hydroxydopamine in comparison with controls. 6-hydroxydopa administration caused an increase of the content of phosphatidylcholine and phosphatidylinositol and decrease of diphosphatidylglycerol in the brain of two weeks old rats. In the brains of six weeks old rats only a decrease in content of phosphatidic acid was observed after administration of either 6-hydroxydopamine or 6-hydroxydopa. The results are further evidence of a nonspecific toxic action of both compounds.
给两周龄和六周龄新生大鼠腹腔注射剂量为50微克/克的6-羟基多巴胺和6-羟基多巴后，与对照组相比，用6-羟基多巴胺处理的两周龄大鼠大脑中磷脂酰胆碱和磷脂酰丝氨酸含量下降，磷脂酰肌醇含量增加。给予6-羟基多巴导致两周龄大鼠大脑中磷脂酰胆碱和磷脂酰肌醇含量增加，二磷脂酰甘油含量下降。在六周龄大鼠的大脑中，给予6-羟基多巴胺或6-羟基多巴后仅观察到磷脂酸含量下降。这些结果进一步证明了这两种化合物的非特异性毒性作用。
