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[对硫磷中毒]

[Parathion poisoning].

作者信息

Bordín C I, Fracapani M T, Carricondo C

出版信息

Bol Med Hosp Infant Mex. 1989 May;46(5):339-42.

PMID:2757776
Abstract

This study shows our clinical and therapeutical experience in 48 cases of infant COFA intoxication admitted in the Intensive Care Unit of "Emilio Civit Children Hospital", Mendoza, Argentina in a periode of seven years. They were investigated to determine the presence of Parathion in blood and gastric washing with the sodium hydroxide qualitative method, and also cholinesterase was detected in blood with a colorimetric method (the monotest cholinesterase). Age range from one to ten years with predominance from 3 to 4 years; 27 were males and 21 females. In almost all the cases (90%) the toxic ingressed through several ways, and from 10 to 30 minutes appeared the characteristic signs: miosis and bronchorrhea. Clinically in 30 cases the intoxication was considered dangerous and mild in the others. The data obtained by laboratory techniques were diagnostic only in half of the cases. Atropine's sulphate was done to all cases until their recuperation, in doses from 2.5 mg to 20 mg. The evolution was highly satisfactory, only two died and two remained with seizures. Always had thanklessness and carelessness with the child from living together adults, who playing handle and waste the toxic. In two occasions the intoxication was familiar by contaminated food.

摘要

本研究展示了我们在七年时间里,对阿根廷门多萨市“埃米利奥·奇维特儿童医院”重症监护病房收治的48例婴儿有机磷农药中毒病例的临床和治疗经验。采用氢氧化钠定性法对血液和洗胃物进行检测,以确定是否存在对硫磷,同时采用比色法(单试剂胆碱酯酶法)检测血液中的胆碱酯酶。年龄范围为1至10岁,以3至4岁为主;男性27例,女性21例。几乎所有病例(90%)的毒物都是通过多种途径进入体内的,中毒后10至30分钟出现特征性体征:瞳孔缩小和支气管分泌过多。临床上,30例中毒被认为危险,其余为轻度。通过实验室技术获得的数据仅在一半的病例中具有诊断价值。所有病例均使用硫酸阿托品进行治疗,直至康复,剂量为2.5毫克至20毫克。治疗效果非常令人满意,仅2例死亡,2例仍有癫痫发作。中毒事件的发生往往是由于与患儿共同生活的成年人疏忽大意,把玩和丢弃毒物所致。有两次中毒事件是由受污染的食物引起的家庭中毒。

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