Soma-Pillay P, Nene Z, Mathivha T M, Macdonald A P
Department of Obstetrics and Gynaecology, Maternal and Fetal Unit.
Department of Cardiology, University of Pretoria and Steve Biko Academic Hospital , Pretoria, South Africa.
Obstet Med. 2011 Mar;4(1):24-7. doi: 10.1258/om.2010.100067. Epub 2011 Mar 1.
There are several challenges in the management of pregnant women with mechanical heart valves. Pregnancy increases the risk of thromboembolism and there is currently no consensus on the safest anticoagulation method during pregnancy. The objective of the study was to determine the correlation between the warfarin dose and pregnancy outcome in pregnant women with prosthetic heart valves. Warfarin in pregnancy was associated with a low risk of valve thrombosis or maternal death. The risk for fetal abnormalities was not related to the maternal warfarin dosage. However, the risk for stillbirth was significantly increased with increasing doses of warfarin.
对于患有机械心脏瓣膜的孕妇的管理存在若干挑战。怀孕会增加血栓栓塞的风险，并且目前对于孕期最安全的抗凝方法尚无共识。该研究的目的是确定人工心脏瓣膜孕妇的华法林剂量与妊娠结局之间的相关性。孕期使用华法林与瓣膜血栓形成或孕产妇死亡的低风险相关。胎儿异常的风险与母亲的华法林剂量无关。然而，随着华法林剂量的增加，死产风险显著增加。
