特应性皮炎：一种皮肤屏障改变和免疫失调的疾病。
Atopic dermatitis: a disease of altered skin barrier and immune dysregulation.
机构信息
Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
出版信息
Immunol Rev. 2011 Jul;242(1):233-46. doi: 10.1111/j.1600-065X.2011.01027.x.
Abstract
Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders. New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies. Patients with AD have a unique predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. Measures directed at healing and protecting the skin barrier and addressing the immune dysregulation are essential in the treatment of patients with AD, and early intervention may improve outcomes for both the skin disease as well as other target organs.
摘要
特应性皮炎（AD）是一种重要的慢性或复发性炎症性皮肤病，常先于哮喘和过敏疾病发生。对 AD 的遗传学和病理生理学的新认识表明，表皮的结构异常以及免疫失调不仅对这种皮肤病，而且对哮喘和过敏的发展都起着重要作用。AD 患者具有独特的倾向，容易被微生物定植或感染，最显著的是金黄色葡萄球菌和单纯疱疹病毒。针对皮肤屏障的修复和保护以及免疫失调的治疗措施是 AD 患者治疗的关键，早期干预可能改善皮肤疾病和其他靶器官的预后。
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2
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J Invest Dermatol. 2011 Jun;131(6):1272-9. doi: 10.1038/jid.2011.24. Epub 2011 Feb 24.
3
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