Gao Xue-Ren, Wang Cui-Min, Wang Wen-Jun, Han Guo-Rong, Zhang Jian-Qiong
Medical School Southeast University, Nanjing, Jiangsu, China.
J Infect Dev Ctries. 2016 Aug 31;10(8):851-6. doi: 10.3855/jidc.6600.
Maternal 25-hydroxyvitamin D [25(OH)D] deficiency has a negative influence on the health of the mother and the developing fetus. The aim of this study was to assess serum 25(OH)D status and its relationship to virologic and biochemical parameters in pregnant women with chronic hepatitis B virus (HBV) infection.
Serum 25(OH)D levels among 142 pregnant women with chronic HBV infection and 251 healthy pregnant women were measured using enzyme-linked immunosorbent assay.
The mean±SD values for serum 25(OH)D levels were 13.63±5.5 ng/mL in healthy pregnant women and 12.05±3.3 ng/mL in pregnant women with chronic HBV infection (p < 0.01). Serum 25(OH)D levels were associated with seasonal variation in healthy pregnant women (p = 0.01); however, similar results were not observed in pregnant women with chronic HBV infection (p = 0.10). Furthermore, multivariate analysis indicated that only ALT level was independently associated with severe vitamin D deficiency (p = 0.01). A significant positive correlation was found between serum 25(OH)D level and ALT level in pregnant women with chronic HBV infection (r = 0.32; p < 0.001).
Vitamin D levels were lower in pregnant women with chronic HBV infection compared with healthy pregnant women. Vitamin D supplementation can be routinely recommended for pregnant women in China.
孕妇25-羟维生素D[25(OH)D]缺乏对母亲及发育中胎儿的健康有负面影响。本研究旨在评估慢性乙型肝炎病毒（HBV）感染孕妇的血清25(OH)D水平及其与病毒学和生化指标的关系。
采用酶联免疫吸附测定法检测142例慢性HBV感染孕妇和251例健康孕妇的血清25(OH)D水平。
健康孕妇血清25(OH)D水平的均值±标准差为13.63±5.5 ng/mL，慢性HBV感染孕妇为12.05±3.3 ng/mL（p<0.01）。健康孕妇血清25(OH)D水平与季节变化相关（p = 0.01）；然而，慢性HBV感染孕妇未观察到类似结果（p = 0.10）。此外，多因素分析表明只有ALT水平与严重维生素D缺乏独立相关（p = 0.01）。慢性HBV感染孕妇血清25(OH)D水平与ALT水平之间存在显著正相关（r = 0.32；p<0.001）。
慢性HBV感染孕妇的维生素D水平低于健康孕妇。在中国可常规推荐对孕妇补充维生素D。
