Imai Noboru
Department of Neurology, Japanese Red Cross Shizuoka Hospital, Japan.
Intern Med. 2016;55(17):2483-5. doi: 10.2169/internalmedicine.55.6621. Epub 2016 Sep 1.
Patients with cluster headaches occasionally fail to respond to conventional preventive treatments. We herein report a case of a patient with a cluster headache in which the symptoms were refractory to conventional preventive treatments except for high-dose glucocorticoids. The headache attacks occurred daily while sleeping, thus the patient suffered from insomnia. Ramelteon, a selective melatonin receptor agonist and a member of a new class of insomnia therapies, completely suppressed the attacks during sleep and provided rapid relief from insomnia. This is the first English case report to describe the efficacy of ramelteon as a preventive treatment for cluster headaches.
丛集性头痛患者偶尔对传统预防性治疗无反应。我们在此报告一例丛集性头痛患者，其症状除高剂量糖皮质激素外对传统预防性治疗无效。头痛发作每天在睡眠时出现，因此患者患有失眠症。雷美替胺是一种选择性褪黑素受体激动剂，属于新型失眠治疗药物，它完全抑制了睡眠期间的发作，并迅速缓解了失眠症状。这是第一份描述雷美替胺作为丛集性头痛预防性治疗药物疗效的英文病例报告。
