University of Michigan Department of Psychiatry & Addiction Research Center, Ann Arbor, MI 48109-2700, USA.
J Clin Sleep Med. 2011 Jun 15;7(3):274-5. doi: 10.5664/JCSM.1070.
In this case series of 5 alcohol-dependent patients with insomnia who had initiated abstinence, a 4-week course of ramelteon 8 mg nightly was associated with markedly improved insomnia scores, increased total sleep time, and decreased time to fall asleep. Given its lack of abuse potential and evidence of low melatonin levels in alcoholism, ramelteon deserves further study as a treatment for insomnia in this group of patients.
在这项 5 例酒精依赖伴失眠患者的病例系列研究中，这些患者在开始戒酒的同时，每晚接受为期 4 周的雷美尔酮 8 毫克治疗，结果显示，其失眠评分显著改善，总睡眠时间增加，入睡时间缩短。鉴于雷美尔酮滥用潜力低，且在酒精中毒患者中存在低褪黑素水平的证据，因此，雷美尔酮作为该类患者失眠的治疗药物值得进一步研究。
