新型氟卟啉-蒽醌配合物作为抗肿瘤剂的设计与合成
Design and Syntheses of Novel Fluoroporphyrin-Anthraquinone Complexes as Antitumor Agents.
作者信息
Yang Gu-Liang, Zhao Sheng-Fang, Chen Nian-You, Li Shiming
机构信息
Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, College of Life Science, Huanggang Normal University.
出版信息
Chem Pharm Bull (Tokyo). 2016;64(9):1310-4. doi: 10.1248/cpb.c16-00308.
A novel fluoroporphyrin-anthraquinone hybrid with dipeptide link and its metal complexes were synthesized and evaluated for anti-proliferation activity in human cancer cell line HeLa. The preliminary results demonstrated that all the compounds showed moderate to excellent antitumor activities. Among the active compounds, compound 3 which contains fluorinated porphyrin-anthraquinone and zinc ion exhibited the highest potency with IC50 value of 8.83 µM, indicating that it was a promising antitumor candidate.
合成了一种具有二肽连接的新型氟卟啉 - 蒽醌杂化物及其金属配合物，并在人癌细胞系HeLa中评估了其抗增殖活性。初步结果表明，所有化合物均表现出中度至优异的抗肿瘤活性。在活性化合物中，含有氟化卟啉 - 蒽醌和锌离子的化合物3表现出最高的活性，IC50值为8.83 μM，表明它是一种有前途的抗肿瘤候选物。
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