State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
School of Pharmacy, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
Molecules. 2019 Aug 20;24(16):3017. doi: 10.3390/molecules24163017.
Herein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency, mild conditions, and benign functional group compatibility was reported. A variety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxybenzoyl)-1-aza-anthraquinone derivatives in good to excellent yields without inert gas and expensive transition metal catalysts. Some compounds displayed good anti-proliferative activities.
本文报道了一种高效、温和、官能团兼容性好的直接合成 3-(2-羟基苯甲酰基)-1-氮杂蒽醌的策略。多种 3-醛基色酮化合物被用作相容的底物，该方法在无需惰性气体和昂贵的过渡金属催化剂的情况下，以良好至优异的收率得到 3-(2-羟基苯甲酰基)-1-氮杂蒽醌衍生物。一些化合物表现出良好的抗增殖活性。
