Bahijri Suhad M, Ahmed Maimoona, Al-Shali Khalid, Bokhari Samia, Alhozali Amani, Borai Anwar, Gusti Amani, Ajabnoor Ghada, Alghamdi Ahmed, Asiri Mohammed, Tuomilehto Jaakko
Department of Clinical Biochemistry, Saudi Diabetes Research Group, Faculty of Medicine, King Abdulaziz University, Jeddah, 21441, Saudi Arabia.
Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ther Adv Chronic Dis. 2016 Sep;7(5):246-54. doi: 10.1177/2040622316658459. Epub 2016 Jul 15.
The aim of this study was to investigate the relationship among management modality, glycemic control, components of metabolic syndrome (MS) and serum levels of γ glutamyl transferase (GGT) and C-reactive protein (CRP) in patients with type 2 diabetes (T2DM).
Patients with T2DM, not suffering from diabetes complications, were recruited from outpatients clinics at two hospitals in Jeddah. Anthropometric measurements and blood pressure (BP) were taken. A treatment plan was recorded. Fasting blood samples were obtained to measure glucose, glycated hemoglobin (HbA1c), lipids profile, highly sensitive (hs)-CRP and GGT.
A total of 71 men and 82 women were recruited. Lower mean HbA1c was found in people receiving oral glucose-lowering drugs compared with those on insulin therapy (p < 0.001). Management modality had no effect on mean GGT or hs-CRP. Higher mean GGT was associated with poor glycemic control, dyslipidemia, hypertension, and abdominal obesity. GGT correlated significantly (p < 0.05) and directly with triglycerides in men (r = 0.401) and diastolic BP (r = 0.279 for men, r = 0.194, for women), but inversely with high-density lipoprotein cholesterol (HDL-C) (r = -0.298 for men, r = -0.171 for women). hs-CRP correlated with waist circumference (p < 0.05, r = 0.312, for men, r = 0.305, for women), with a higher mean being found in men with poor glycemic control (p = 0.015), in hypertensive women (p = 0.030), and in patients who were abdominally obese (p < 0.05).
High levels of GGT and hs-CRP are associated with components of MS and poor glycemic control, hence increased cardiovascular risk. Due to their value as independent risk predictors of vascular injury, these measures should be included in routine monitoring of patients with T2DM.
本研究旨在调查2型糖尿病（T2DM）患者的管理方式、血糖控制、代谢综合征（MS）各组分与γ-谷氨酰转移酶（GGT）及C反应蛋白（CRP）血清水平之间的关系。
从吉达两家医院的门诊招募无糖尿病并发症的T2DM患者。进行人体测量和血压（BP）测量。记录治疗方案。采集空腹血样以测量血糖、糖化血红蛋白（HbA1c）、血脂谱、高敏（hs）-CRP和GGT。
共招募了71名男性和82名女性。与接受胰岛素治疗的患者相比，接受口服降糖药治疗的患者平均HbA1c较低（p < 0.001）。管理方式对平均GGT或hs-CRP无影响。较高的平均GGT与血糖控制不佳、血脂异常、高血压和腹型肥胖相关。GGT与男性甘油三酯（r = 0.401）及舒张压（男性r = 0.279，女性r = 0.194）显著正相关（p < 0.05），但与高密度脂蛋白胆固醇（HDL-C）呈负相关（男性r = -0.298，女性r = -0.171）。hs-CRP与腰围相关（p < 0.05，男性r = 0.312，女性r = 0.305），血糖控制不佳的男性（p = 0.015）、高血压女性（p = 0.030）及腹型肥胖患者（p < 0.05）的平均hs-CRP较高。
高水平的GGT和hs-CRP与MS各组分及血糖控制不佳相关，因此心血管风险增加。鉴于它们作为血管损伤独立风险预测指标的价值，这些指标应纳入T2DM患者的常规监测中。
