Bradley Ryan D, Fitzpatrick Annette L, Jacobs David R, Lee Duk-Hee, Swords Jenny Nancy, Herrington David
Bastyr University California, 4106 Sorrento Valley Blvd., San Diego, CA 92121, USA; University of Washington, USA.
University of Washington, USA.
Atherosclerosis. 2014 Apr;233(2):387-393. doi: 10.1016/j.atherosclerosis.2014.01.010. Epub 2014 Jan 21.
To evaluate associations between total serum γ-glutamyltransferase activity (GGT) and biomarkers of arteriosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA), including 6783 participants from four ethnic subgroups, i.e., White, Chinese, Black and Hispanic.
Associations between fasting total serum GGT activity and oxidized low-density lipoproteins (oxLDL), interleukin-6 (IL-6), C-reactive protein (CRP), and soluble intercellular adhesion molecule-1 (sICAM-1) were assessed. Following evaluation of linear trends between GGT and biomarkers of interest, multivariable linear regression models were serially adjusted for age, gender, site, ethnicity (M1); M1+lifestyle variables (M2); M2+traditional cardiovascular risk factors plus medications (M3); and M3+metabolic status (M4). Interactions were evaluated between GGT and age and ethnicity in all models.
Linear trends were positive and significant between GGT and oxLDL, IL-6, CRP and sICAM-1 in crude models, and trends remained significant in all ethnic subgroups for CRP (p<0.0001) and sICAM-1 (p<0.001), and for IL-6 except in the Chinese. Trends between GGT and oxLDL were significant in the entire cohort and the White subgroup (p<0.0001), but not in other ethnic subgroups. Multivariable models demonstrated continuous strong, positive associations between GGT and CRP, IL-6 and sICAM-1. Associations between GGT and oxLDL were attenuated upon adjustment for LDL-C and other traditional risk factors. All models were attenuated with adjustment for metabolic status. No age interactions were evident.
Our findings support the hypothesis that total serum GGT activity represents the impact of metabolic disease on vascular injury and atherosclerosis.
在动脉粥样硬化多族裔研究（MESA）中评估血清总γ-谷氨酰转移酶活性（GGT）与动脉粥样硬化生物标志物之间的关联，该研究包括来自四个族裔亚组（即白人、华裔、黑人及西班牙裔）的6783名参与者。
评估空腹血清总GGT活性与氧化型低密度脂蛋白（oxLDL）、白细胞介素-6（IL-6）、C反应蛋白（CRP）及可溶性细胞间黏附分子-1（sICAM-1）之间的关联。在评估GGT与相关生物标志物之间的线性趋势后，多变量线性回归模型依次针对年龄、性别、研究地点、种族（模型1）；模型1+生活方式变量（模型2）；模型2+传统心血管危险因素及药物（模型3）；以及模型3+代谢状态（模型4）进行调整。在所有模型中评估GGT与年龄及种族之间的相互作用。
在未调整模型中，GGT与oxLDL、IL-6、CRP及sICAM-1之间呈显著正线性趋势，对于CRP（p<0.0001）和sICAM-1（p<0.001），以及除华裔外的IL-6，在所有族裔亚组中该趋势均保持显著。GGT与oxLDL之间的趋势在整个队列及白人亚组中显著（p<0.0001），但在其他族裔亚组中不显著。多变量模型显示GGT与CRP、IL-6及sICAM-1之间持续存在强正相关。在调整低密度脂蛋白胆固醇（LDL-C）及其他传统危险因素后，GGT与oxLDL之间的关联减弱。在调整代谢状态后，所有模型的关联均减弱。未发现明显的年龄相互作用。
我们的研究结果支持以下假设，即血清总GGT活性反映了代谢性疾病对血管损伤和动脉粥样硬化的影响。
