Hamon C G, Cutler P, Blair J A
Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham, UK.
Clin Chim Acta. 1989 May 31;181(3):249-53. doi: 10.1016/0009-8981(89)90230-1.
Streptozotocin induced diabetes has been shown to have associated changes in the metabolism of tetrahydrobiopterin. De novo biosynthesis of tetrahydrobiopterin in the brain was reduced as was dihydropteridine reductase activity. Consequently there is a shift from fully reduced biopterins to more oxidised species. Both can cause reduced levels in the cofactor pool and may cause reduced levels of the associated neurotransmitters and neurological deficits.
链脲佐菌素诱导的糖尿病已被证明与四氢生物蝶呤代谢的相关变化有关。大脑中四氢生物蝶呤的从头生物合成减少，二氢蝶啶还原酶活性也降低。因此，从完全还原的生物蝶呤向更氧化的形式转变。两者都会导致辅因子池水平降低，并可能导致相关神经递质水平降低和神经功能缺损。
