McIntosh M J, Meredith P A, Moore M R, Goldberg A
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;81(1):227-31. doi: 10.1016/0742-8413(85)90120-3.
The effects of lead, a known neurotoxin on the metabolism of a vital tetrahydrobiopterin cofactor for the hydroxylation enzymes tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase, have been investigated. Reduced availability of this pteridine has the potential to reduce the level of the neurotransmitters noradrenaline, adrenaline and 5-hydroxytryptophan in the brain. Using the rat as a model, increases in tetrahydrobiopterin concentration and in the activity of dihydropteridine reductase, an enzyme involved in tetrahydrobiopterin metabolism, were observed after exposure to lead via the drinking water. Possible explanations for this increased level of tetrahydrobiopterin relate to alterations in the balance between synthesis and salvage of this co-factor.
铅是一种已知的神经毒素，其对酪氨酸羟化酶、苯丙氨酸羟化酶和色氨酸羟化酶等羟基化酶的重要四氢生物蝶呤辅因子代谢的影响已得到研究。这种蝶啶可用性的降低有可能降低大脑中去甲肾上腺素、肾上腺素和5-羟色氨酸等神经递质的水平。以大鼠为模型，通过饮用水接触铅后，观察到四氢生物蝶呤浓度以及参与四氢生物蝶呤代谢的二氢蝶呤还原酶活性增加。四氢生物蝶呤水平升高的可能解释与该辅因子合成与补救之间平衡的改变有关。
