捕获-塌缩杂环化反应：通过从环戊二酮铑中进行碳-氮还原消除反应合成1,3-二氮杂环庚烷。

Capture-Collapse Heterocyclization: 1,3-Diazepanes by C-N Reductive Elimination from Rhodacyclopentanones.

作者信息

McCreanor Niall G, Stanton Steven, Bower John F

机构信息

School of Chemistry, University of Bristol , Bristol, BS8 1TS, United Kingdom.

出版信息

J Am Chem Soc. 2016 Sep 14;138(36):11465-8. doi: 10.1021/jacs.6b07046. Epub 2016 Sep 2.

DOI:10.1021/jacs.6b07046

PMID:27589060

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5025829/

Abstract

Rhodacyclopentanones derived from carbonylative C-C activation of cyclopropyl ureas can be "captured" by pendant nucleophiles prior to "collapse" to 1,3-diazepanes. The choice of N-substituent on the cyclopropane unit controls the oxidation level of the product, such that C4-C5 unsaturated or saturated systems can be accessed selectively.

摘要

源自环丙基脲的羰基化C-C活化反应生成的环戊二酮，在“分解”为1,3-二氮杂环庚烷之前，可被侧链亲核试剂“捕获”。环丙烷单元上N-取代基的选择控制着产物的氧化态，从而能够选择性地得到C4-C5不饱和或饱和体系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715e/5025829/ed49da8a581c/ja-2016-07046m_0001.jpg

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捕获-塌缩杂环化反应：通过从环戊二酮铑中进行碳-氮还原消除反应合成1,3-二氮杂环庚烷。

Capture-Collapse Heterocyclization: 1,3-Diazepanes by C-N Reductive Elimination from Rhodacyclopentanones.

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捕获-塌缩杂环化反应：通过从环戊二酮铑中进行碳-氮还原消除反应合成1,3-二氮杂环庚烷。

Capture-Collapse Heterocyclization: 1,3-Diazepanes by C-N Reductive Elimination from Rhodacyclopentanones.

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