Xue Hao, Wang Jianli, Hou Jinhong, Zhu Hang, Gao Jingsheng, Chen Shuohua, Wang Yutang, Chen Yundai, Wu Shouling
Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China.
Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan, People's Republic of China.
PLoS One. 2013 Dec 11;8(12):e81597. doi: 10.1371/journal.pone.0081597. eCollection 2013.
Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) are associated with increased risk of cardiovascular disease. However, ideal cardiovascular health indicates lower risk of cardiovascular disease. This study aimed to investigate the effect of ideal cardiovascular health behaviors and health factors on hs-CRP levels among a hypertensive population. From 2006 to 2007, a cross-sectional study was conducted to survey 41,476 hypertensive subjects among the employees of Kailuan Corporation. Data from unified questionnaires and blood biochemical examinations were collected. The effects of ideal cardiovascular health behaviors and health factors on hs-CRP levels were evaluated through multivariate logistic regression analysis. A negative correlation was observed between hs-CRP levels and the number of ideal cardiovascular health metrics. The mean hs-CRP levels of subjects with zero to one, two, three, and four to six ideal cardiovascular health metrics were 1.11, 0.96, 0.90, and 0.80 mg/L, respectively (P<0.01). Multivariate logistic regression analysis revealed that after adjustment for sex, age, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and other risk factors, the risks for subjects with two, three, and four to six ideal health metrics with serum hs-CRP >3 mg/L were lower than those with zero to one ideal health metrics, with corresponding odd ratios of 0.86 (95%CI: 0.79-0.93, P<0.01), 0.76 (95%CI: 0.69-0.83, P<0.01), and 0.68 (95%CI: 0.64-0.75, P<0.01), respectively. This finding suggests that ideal cardiovascular health behaviors and health factors were related to decreased hs-CRP levels in a hypertensive population.
UNIQUE IDENTIFIER: ChiCTR-TNC-11001489.
炎症生物标志物高敏C反应蛋白（hs-CRP）水平升高与心血管疾病风险增加相关。然而，理想的心血管健康意味着心血管疾病风险较低。本研究旨在调查理想的心血管健康行为和健康因素对高血压人群hs-CRP水平的影响。2006年至2007年，开展了一项横断面研究，对开滦集团员工中的41476名高血压受试者进行了调查。收集了统一问卷和血液生化检查的数据。通过多因素逻辑回归分析评估理想的心血管健康行为和健康因素对hs-CRP水平的影响。观察到hs-CRP水平与理想心血管健康指标数量之间呈负相关。具有零至一项、两项、三项以及四项至六项理想心血管健康指标的受试者的hs-CRP平均水平分别为1.11、0.96、0.90和0.80mg/L（P<0.01）。多因素逻辑回归分析显示，在调整性别、年龄、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和其他风险因素后，具有两项、三项以及四项至六项理想健康指标且血清hs-CRP>3mg/L的受试者的风险低于具有零至一项理想健康指标的受试者，相应的比值比分别为0.86（95%CI：0.79-0.93，P<0.01）、0.76（95%CI：0.69-0.83，P<0.01）和0.68（95%CI：0.64-0.75，P<0.01）。这一发现表明，理想的心血管健康行为和健康因素与高血压人群hs-CRP水平降低有关。
唯一标识符：ChiCTR-TNC-11001489。
