患有和不患有感染的女性的妊娠的母婴和新生儿结局。
Maternal, Fetal, and Neonatal Outcomes of Gestation in Women with and Without Infection.
机构信息
Infectious Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Infectious Diseases, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
J Res Health Sci. 2023 Mar;23(1):e00575. doi: 10.34172/jrhs.2023.110.
BACKGROUND
Maternal, fetal, and neonatal complications of brucellosis in pregnant women are probably higher than those in the general population. This comparative study aimed to survey the mentioned complications in pregnant women with positive and negative serologic tests.
STUDY DESIGN
This is a prospective cohort study.
METHODS
In this study, 2160 pregnant women residing in the rural area of Hamadan province were screened for infection by agglutination test. Then, 106 (4.90%) pregnant women with a positive test (exposed group) were compared with 210 subjects (non-exposed group) who were randomly selected from more than 2000 pregnant women with a negative serological test in terms of maternal, fetal, and neonatal outcomes from October 2018 to March 2020. Data were analyzed by SPSS 20 software at a 95% confidence level.
RESULTS
The mean age of mothers in both exposed and unexposed groups was 27.84±6.13 and 38.71±6.85 years, respectively. Past medical history of brucellosis, animal contact, and the consumption of unpasteurized dairy products were reported to be 14 (13.2%), 63 (59.4%), and 82 (77.4%), respectively, in the exposed group. The mentioned measures were 3 (1.5%), 109 (51.9%), and 54 (26.9%) in the unexposed group, respectively. Among exposed and unexposed groups, the incidence of abortion was 9 (8.6%) and 5 (2.4%) with =0.005, intrauterine fetal death was 2 (1.9%) and zero with =0.211, low birth weight was 10 (10.6%) and 7 (3.4%) with =0.012, and premature birth was 15 (15.2%) and 18 (8.8%) with =0.066, respectively.
CONCLUSION
Brucella infection in pregnant women appears to be associated with the risk of miscarriage, low birth weight, and premature birth.
背景
孕妇布鲁氏菌病的母婴和新生儿并发症可能高于一般人群。本项对照研究旨在调查血清学检测阳性和阴性的孕妇的上述并发症。
研究设计
这是一项前瞻性队列研究。
方法
本研究对居住在哈马丹省农村地区的 2160 名孕妇进行了凝集试验筛查。然后，将 106 名（4.90%）血清学检测阳性（暴露组）的孕妇与 2018 年 10 月至 2020 年 3 月期间 210 名（非暴露组）随机选择的 2000 多名血清学检测阴性的孕妇进行比较，比较母婴和新生儿结局。数据采用 SPSS 20 软件在 95%置信水平下进行分析。
结果
暴露组和未暴露组母亲的平均年龄分别为 27.84±6.13 岁和 38.71±6.85 岁。暴露组有 14 例（13.2%）有布鲁氏菌病既往病史，63 例（59.4%）有动物接触史，82 例（77.4%）有食用未巴氏消毒乳制品史。未暴露组有 3 例（1.5%）有布鲁氏菌病既往病史，109 例（51.9%）有动物接触史，54 例（26.9%）有食用未巴氏消毒乳制品史。在暴露组和未暴露组中，流产发生率分别为 9 例（8.6%）和 5 例（2.4%），差异有统计学意义（=0.005）；宫内胎儿死亡发生率分别为 2 例（1.9%）和 0 例，差异无统计学意义（=0.211）；低出生体重发生率分别为 10 例（10.6%）和 7 例（3.4%），差异有统计学意义（=0.012）；早产发生率分别为 15 例（15.2%）和 18 例（8.8%），差异无统计学意义（=0.066）。
结论
孕妇布鲁氏菌感染似乎与流产、低出生体重和早产的风险相关。
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