Department of Respiration and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Respiration and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ann Allergy Asthma Immunol. 2016 Oct;117(4):417-422.e1. doi: 10.1016/j.anai.2016.08.001. Epub 2016 Aug 31.
The association between MBL2 gene polymorphisms and the risk of asthma has been evaluated in multiple studies; however, the results are inconsistent.
To perform a meta-analysis to explore whether MBL2 gene polymorphisms were associated with the risk of asthma.
We searched PubMed, Web of Science, and Cochrane Library to find relevant articles published up to March 2016. Nine studies, including 2066 cases and 2183 controls, were included in the meta-analysis. The strength of association was evaluated by odds ratio (OR) with 95% confidence interval (CI).
The results reveal that MBL2 gene polymorphisms (codon 54 A/B, -550 H/L or -221 X/Y) were not associated with the risk of asthma (codon 54 A/B: BB+AB vs AA: OR, 1.02; 95% CI, 0.85-1.23; -550 H/L: LL+HL vs HH: OR, 0.81; 95% CI, 0.63-1.03; -221 X/Y: XX+YX vs YY: OR, 0.85; 95% CI, 0.69-1.04). Subgroup analysis by ethnicity implied that the MBL2 codon 54 A/B polymorphism was not significantly associated with the risk of asthma in Asians (BB+AB vs AA: OR, 0.95; 95% CI, 0.70-1.29) or whites (BB+AB vs AA: OR, 1.07; 95% CI, 0.84-1.35).
The results indicated that MBL2 gene polymorphisms (codon 54 A/B, -550 H/L or -221 X/Y) may be not associated with the risk of asthma.
多项研究评估了甘露聚糖结合凝集素 2（MBL2）基因多态性与哮喘风险之间的关联，但结果并不一致。
进行荟萃分析以探讨 MBL2 基因多态性是否与哮喘风险相关。
我们检索了 PubMed、Web of Science 和 Cochrane Library，以查找截至 2016 年 3 月发表的相关文章。共有 9 项研究纳入了荟萃分析，包括 2066 例病例和 2183 例对照。采用比值比（OR）及其 95%置信区间（CI）来评估关联强度。
结果显示，MBL2 基因多态性（密码子 54 A/B、-550 H/L 或-221 X/Y）与哮喘风险无关（密码子 54 A/B：BB+AB 与 AA：OR，1.02；95%CI，0.85-1.23；-550 H/L：LL+HL 与 HH：OR，0.81；95%CI，0.63-1.03；-221 X/Y：XX+YX 与 YY：OR，0.85；95%CI，0.69-1.04）。按种族进行的亚组分析表明，MBL2 密码子 54 A/B 多态性与亚洲人（BB+AB 与 AA：OR，0.95；95%CI，0.70-1.29）或白种人（BB+AB 与 AA：OR，1.07；95%CI，0.84-1.35）哮喘风险无关。
结果表明，MBL2 基因多态性（密码子 54 A/B、-550 H/L 或-221 X/Y）可能与哮喘风险无关。
