Shi Jing, Xie Min, Wang Jian-Miao, Xu Yong-Jian, Xiong Wei-Ning, Liu Xian-Sheng
Department of Respiration and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
J Huazhong Univ Sci Technolog Med Sci. 2013 Apr;33(2):166-171. doi: 10.1007/s11596-013-1091-1. Epub 2013 Apr 17.
Numerous studies have been done to explore the association between mannose-binding lectin two (MBL2) gene polymorphisms and the risk of tuberculosis (TB). However, the results are inconsistent. We performed a meta-analysis to investigate whether polymorphisms in the MBL2 gene were associated with TB risk. Databases including PubMed, Medline, Chinese Biomedicine Database, China National Knowledge Infrastructure, Wanfang Database, and Weipu Database were searched to find relevant articles published up to 2 October, 2012. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of association. All statistical tests were performed by using Revman 5.1 software and STATA 11.0 software. Six case-control studies including 1106 cases and 1190 controls were accepted in the meta-analysis. The results indicated that individuals carrying the MBL2 codon 54 B allele may have an increased risk of TB as compared with AA homozygotes (BB+AB vs. AA: OR=1.52, 95% CI: 1.22-1.88), whereas MBL2 +4 P/Q was possibly not associated with TB susceptibility in Chinese population.
已经开展了大量研究来探索甘露糖结合凝集素2（MBL2）基因多态性与结核病（TB）风险之间的关联。然而，结果并不一致。我们进行了一项荟萃分析，以研究MBL2基因多态性是否与结核病风险相关。检索了包括PubMed、Medline、中国生物医学数据库、中国知网、万方数据库和维普数据库在内的数据库，以查找截至2012年10月2日发表的相关文章。采用比值比（OR）及95%置信区间（CI）来评估关联强度。所有统计检验均使用Revman 5.1软件和STATA 11.0软件进行。荟萃分析纳入了6项病例对照研究，共1106例病例和1190例对照。结果表明，与AA纯合子相比，携带MBL2密码子54 B等位基因的个体患结核病的风险可能增加（BB + AB与AA相比：OR = 1.52，95% CI：1.22 - 1.88），而在中国人群中，MBL2 +4 P/Q可能与结核病易感性无关。
